Tyro3

Tyro3 Products

All (8)
Tyro3 Inhibitors (7)
Tyro3 Antibodie (1)
New Tyro3 Products

Catalog No.	Product Name	Information	Product Use Citations
S1561	BMS-777607	BMS-777607 (BMS 817378) is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM in cell-free assays, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.	Cancer Lett, 2024, 587:216692 Nat Commun, 2023, 14(1):4162 Oncogene, 2023, 42(21):1716-1727
S7638	LDC1267	LDC1267 is a highly selective TAM kinase inhibitor with IC50 of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Displays lower activity against Met, Aurora B, Lck, Src, and CDK8.	Cell Metab, 2021, S1550-4131(21)00326-0 J Clin Invest, 2021, 131(8)e139434 139434 J Clin Invest, 2021, 131(8)139434
S7576	UNC2025 HCl	UNC2025 HCl is a potent and orally bioavailable dual MER/FLT3 inhibitor with IC50 of 0.74 nM and 0.8 nM, respectively, about 20-fold selectivity over Axl and Tyro3.	Immunity, 2023, 56(8):1778-1793.e10 Cell Rep, 2022, 38(13):110600 Cancers (Basel), 2021, 13(23)6072
S9662	UNC2025	UNC2025 is a potent and orally active dual inhibitor of FLT3 and MER with IC50 of 0.35 nM and 0.46 nM, respectively. UNC2025 also inhibits AXL, TRKA, TRKC, QIK, TYRO3, SLK, NuaK1, Kit (c-Kit) and Met (c-Met) with IC50 of 1.65 nM, 1.67 nM, 4.38 nM, 5.75 nM, 5.83 nM, 6.14 nM, 7.97 nM, 8.18 nM and 364 nM, respectively.	iScience, 2024, 27(7):110226 Commun Biol, 2023, 6(1):916 Commun Biol, 2023, 6(1):916
S8570	CEP-40783 (RXDX-106)	CEP-40783 (RXDX-106) is an orally-available, potent and selective TAM(TYRO3, AXL, MER)/Met (c-Met) inhibitor displaying low nanomolar biochemical activity and slow (T1/2 >120 min) inhibitor off-rate in peptide phosphorylation assays and in vitro kinase binding assays, respectively.	bioRxiv, 2023, 2023.10.20.563266 Mol Cancer Res, 2022, 20(4):542-555 J Oncol, 2022, 2022:2946929
S7325	UNC2881	UNC2881 is a specific Mer tyrosine kinase inhibitor with IC50 of 4.3 nM, about 83- and 58-fold selectivity over Axl and Tyro3, respectively.	Cell Rep, 2020, 30(11):3671-3681 Front Immunol, 2019, 10:2647
S0071	RU-301	RU-301 is a pan-TAM receptor (Axl, Tyro3 and Mertk) inhibitor that blocks the Axl receptor dimerization site with Kd of 12 μM and IC50 of 10 μM, respectively.
A2698	Anti-TYRO3 (ELB031)	Anti-TYRO3 (ELB031) is a monoclonal antibody that targets TYRO3 and MERTK.
S1561	BMS-777607	BMS-777607 (BMS 817378) is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM in cell-free assays, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.	Cancer Lett, 2024, 587:216692 Nat Commun, 2023, 14(1):4162 Oncogene, 2023, 42(21):1716-1727
S7638	LDC1267	LDC1267 is a highly selective TAM kinase inhibitor with IC50 of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Displays lower activity against Met, Aurora B, Lck, Src, and CDK8.	Cell Metab, 2021, S1550-4131(21)00326-0 J Clin Invest, 2021, 131(8)e139434 139434 J Clin Invest, 2021, 131(8)139434
S7576	UNC2025 HCl	UNC2025 HCl is a potent and orally bioavailable dual MER/FLT3 inhibitor with IC50 of 0.74 nM and 0.8 nM, respectively, about 20-fold selectivity over Axl and Tyro3.	Immunity, 2023, 56(8):1778-1793.e10 Cell Rep, 2022, 38(13):110600 Cancers (Basel), 2021, 13(23)6072
S9662	UNC2025	UNC2025 is a potent and orally active dual inhibitor of FLT3 and MER with IC50 of 0.35 nM and 0.46 nM, respectively. UNC2025 also inhibits AXL, TRKA, TRKC, QIK, TYRO3, SLK, NuaK1, Kit (c-Kit) and Met (c-Met) with IC50 of 1.65 nM, 1.67 nM, 4.38 nM, 5.75 nM, 5.83 nM, 6.14 nM, 7.97 nM, 8.18 nM and 364 nM, respectively.	iScience, 2024, 27(7):110226 Commun Biol, 2023, 6(1):916 Commun Biol, 2023, 6(1):916
S8570	CEP-40783 (RXDX-106)	CEP-40783 (RXDX-106) is an orally-available, potent and selective TAM(TYRO3, AXL, MER)/Met (c-Met) inhibitor displaying low nanomolar biochemical activity and slow (T1/2 >120 min) inhibitor off-rate in peptide phosphorylation assays and in vitro kinase binding assays, respectively.	bioRxiv, 2023, 2023.10.20.563266 Mol Cancer Res, 2022, 20(4):542-555 J Oncol, 2022, 2022:2946929
S7325	UNC2881	UNC2881 is a specific Mer tyrosine kinase inhibitor with IC50 of 4.3 nM, about 83- and 58-fold selectivity over Axl and Tyro3, respectively.	Cell Rep, 2020, 30(11):3671-3681 Front Immunol, 2019, 10:2647
S0071	RU-301	RU-301 is a pan-TAM receptor (Axl, Tyro3 and Mertk) inhibitor that blocks the Axl receptor dimerization site with Kd of 12 μM and IC50 of 10 μM, respectively.
A2698	Anti-TYRO3 (ELB031)	Anti-TYRO3 (ELB031) is a monoclonal antibody that targets TYRO3 and MERTK.

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