Home Protein Tyrosine Kinase Mertk inhibitor - Axl inhibitor - Tyro3 inhibitor UNC2881 For research use only.

UNC2881

UNC2881 is a specific Mer tyrosine kinase inhibitor with IC50 of 4.3 nM, about 83- and 58-fold selectivity over Axl and Tyro3, respectively.

UNC2881 Chemical Structure

UNC2881 Chemical Structure

CAS No. 1493764-08-1

Purity & Quality Control

UNC2881 Related Products

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
697 B-ALL cells Function assay 1 h Inhibition of Mer kinase phosphorylation in human 697 B-ALL cells after 1 hr by Western blot analysis, IC50=0.022 μM 24219778
mouse 32D-EMC cells Function assay Inhibition of EGF-induced human intracellular domain of Mer/extracellular domain of EGFR phosphorylation expressed in mouse 32D-EMC cells after 1 hr by Western blot analysis 24219778
Click to View More Cell Line Experimental Data

Biological Activity

Description UNC2881 is a specific Mer tyrosine kinase inhibitor with IC50 of 4.3 nM, about 83- and 58-fold selectivity over Axl and Tyro3, respectively.
Targets
Mer [1]
(Cell-free assay)		 Tyro3 [1]
(Cell-free assay)
4.3 nM 250 nM
In vitro
In vitro UNC2881 inhibits Mer kinase activity in 697 B-ALL cells with IC50 of 22 nM, and inhibits collagen-stimulated platelet aggregation. [1]
In Vivo
In vivo UNC2881 have high systemic clearance (94.5 mL/min/kg) and 14% oral bioavailability in mice. [1]
Animal Research Animal Models Swiss albino mice
Dosages ~3 mg/kg
Administration i.v. or p.o.

Chemical Information & Solubility

Molecular Weight 463.58 Formula

C25H33N7O2
CAS No. 1493764-08-1 SDF Download UNC2881 SDF
Smiles CCCCNC1=NC=C(C(=N1)NC2CCC(CC2)O)C(=O)NCC3=CC=C(C=C3)N4C=CN=C4
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 92 mg/mL ( (198.45 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 7 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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