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Thioredoxin Reductase

Isoform-selective Products

TrxR

Thioredoxin Reductase Products

All (3)
Thioredoxin Reductase Inhibitors (3)
New Thioredoxin Reductase Products

Catalog No.	Product Name	Information	Product Use Citations	Product Validations
S8068	Chaetocin	Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of thioredoxin reductase (TrxR).	PeerJ, 2024, 12:e17222 Asian Pac J Trop Bio, 2023;, 13(6): 268-276 Cancer Cell, 2023, 41(6):1118-1133.e12
S4307	Auranofin	Auranofin is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.	Adv Healthc Mater, 2023, e2300591. Theranostics, 2022, 12(12):5451-5469 Oncotarget, 2018,
S0267	TRi-1	TRi-1 (HUN20688, TXNRD1 inhibitor 1) is a potent, specific and irreversible cytosolic thioredoxin reductase 1 (TXNRD1) inhibitor with IC50 of 12 nM. TRi-1 exhibits anti-cancer activity while having little mitochondrial toxicity.	Int J Mol Sci, 2023, 24(15)12460 Oxid Med Cell Longev, 2022, 2022:7067623
S8068	Chaetocin	Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of thioredoxin reductase (TrxR).	PeerJ, 2024, 12:e17222 Asian Pac J Trop Bio, 2023;, 13(6): 268-276 Cancer Cell, 2023, 41(6):1118-1133.e12
S4307	Auranofin	Auranofin is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.	Adv Healthc Mater, 2023, e2300591. Theranostics, 2022, 12(12):5451-5469 Oncotarget, 2018,
S0267	TRi-1	TRi-1 (HUN20688, TXNRD1 inhibitor 1) is a potent, specific and irreversible cytosolic thioredoxin reductase 1 (TXNRD1) inhibitor with IC50 of 12 nM. TRi-1 exhibits anti-cancer activity while having little mitochondrial toxicity.	Int J Mol Sci, 2023, 24(15)12460 Oxid Med Cell Longev, 2022, 2022:7067623

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Tags: Thioredoxin Reductase inhibitor|Thioredoxin Reductase agonist|Thioredoxin Reductase activator|Thioredoxin Reductase inducer|Thioredoxin Reductase antagonist|Thioredoxin Reductase signaling pathway|Thioredoxin Reductase assay kit