Home Microbiology Bacterial inhibitor - Thioredoxin Reductase inhibitor Auranofin For research use only.

Auranofin

Synonyms: SKF39162

Auranofin is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.

Auranofin Chemical Structure

Auranofin Chemical Structure

CAS No. 34031-32-8

Purity & Quality Control

Auranofin Related Products

Biological Activity

Description Auranofin is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.
Targets
TrxR [1]
(Cell-free assay)
88 nM
In vitro
In vitro

Auranofin (Ridaura, SKF-39162) is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay.
In Vivo
In vivo

Auranofin is a small molecule inhibitor of NONO that suppressed GBM tumor growth in an orthotopic xenograft model in mice.
Animal Research Animal Models Athymic nude mice
Dosages 5 or 10 mg/kg
Administration o.g.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02089048 Completed
Amoebiasis
National Institute of Allergy and Infectious Diseases (NIAID)
 April 2 2014 Phase 1
NCT01747798 Completed
Recurrent Fallopian Tube Cancer|Recurrent Ovarian Epithelial Cancer|Recurrent Primary Peritoneal Cavity Cancer
Mayo Clinic
 November 2 2012 Early Phase 1
NCT01419691 Completed
Chronic Lymphocytic Leukemia (CLL)|Small Lymphocytic Lymphoma|Leukemia Prolymphocytic
University of Kansas Medical Center|The Leukemia and Lymphoma Society|Kansas Bioscience Authority|Therapeutics for Rare and Neglected Diseases (TRND)
 September 2011 Phase 2
NCT02176135 Withdrawn
HIV
Vaccine and Gene Therapy Institute Florida|University of Miami
 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 678.48 Formula

C20H34AuO9PS
CAS No. 34031-32-8 SDF Download Auranofin SDF
Smiles CCP(CC)CC.CC(=O)OCC1C(C(C(C(O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au+]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (147.38 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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