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Pyroptosis

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Pyroptosis Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S1680 Disulfiram Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH) with IC50 of 0.15 μM and 1.45 μM for hALDH1 and hALDH2, respectively. Disulfiram is used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram induces apoptosis. Disulfiram is also an inhibitor of pore formation by gasdermin D (GSDMD).
Bioact Mater, 2024, 36:238-255
Cell Death Dis, 2023, 14(12):825
J Transl Med, 2023, 21(1):334
S9302 Polyphyllin VI Polyphyllin VI derived from Paris polyphylla possess anti-cancer activities.
Redox Biol, 2024, 70:103039
Int J Oral Sci, 2024, 16(1):3
bioRxiv, 2024, 2024.03.19.585812
S9817 Ac-FLTD-CMK Ac-FLTD-CMK is a specific inhibitor for inflammatory caspases. Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. Ac-FLTD-CMK is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively.
Biomolecules, 2022, 12(11)1660
S9622 LDC7559 LDC7559 is a potent Gasdermin D(GSDMD) inhibitor inhibiting the pyroptosis and lessens its inflammation.
iScience, 2024, 27(5):109774
Heliyon, 2024, 10(11):e32571
S5465 Morroniside Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption. Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.
S1680 Disulfiram Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH) with IC50 of 0.15 μM and 1.45 μM for hALDH1 and hALDH2, respectively. Disulfiram is used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram induces apoptosis. Disulfiram is also an inhibitor of pore formation by gasdermin D (GSDMD).
Bioact Mater, 2024, 36:238-255
Cell Death Dis, 2023, 14(12):825
J Transl Med, 2023, 21(1):334
S9817 Ac-FLTD-CMK Ac-FLTD-CMK is a specific inhibitor for inflammatory caspases. Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. Ac-FLTD-CMK is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively.
Biomolecules, 2022, 12(11)1660
S9622 LDC7559 LDC7559 is a potent Gasdermin D(GSDMD) inhibitor inhibiting the pyroptosis and lessens its inflammation.
iScience, 2024, 27(5):109774
Heliyon, 2024, 10(11):e32571
S5465 Morroniside Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption. Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.
S9302 Polyphyllin VI Polyphyllin VI derived from Paris polyphylla possess anti-cancer activities.
Redox Biol, 2024, 70:103039
Int J Oral Sci, 2024, 16(1):3
bioRxiv, 2024, 2024.03.19.585812

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