Home Apoptosis MDM2/MDMX antagonist YH239-EE For research use only.

YH239-EE

YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.

YH239-EE Chemical Structure

YH239-EE Chemical Structure

CAS No. 1364488-67-4

Purity & Quality Control

Batch: S748901 DMSO]100 mg/mL]false]Ethanol]18 mg/mL]false]Water]Insoluble]false Purity: 99.88%
99.88

YH239-EE Related Products

Signaling Pathway

MDM2/MDMX Signaling Pathways

MDM2/MDMX Signaling Pathway

Biological Activity

Description YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
Targets
p53-MDM2 interaction [1]
In vitro
In vitro YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion). [1]
Cell Research Cell lines OCI-AML-3 cells
Concentrations ~50 μM
Incubation Time 72 hours
Method Cell lines are harvested in log-phase growth and seeded following exposure to p53-MDM2 antagonists. Cell number and viability are determined by staining cells with Trypan blue 0.4% and counted with Countess slides.

Chemical Information & Solubility

Molecular Weight 504.41 Formula

C25H27Cl2N3O4
CAS No. 1364488-67-4 SDF Download YH239-EE SDF
Smiles CCOC(=O)C1=C(C2=C(N1)C=C(C=C2)Cl)C(C(=O)NC(C)(C)C)N(CC3=CC=C(C=C3)Cl)C=O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (198.25 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 18 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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