Xentuzumab (Anti-IGF-1)

Synonyms: BI 836845; Anti-Human IGF-1 and IGF-2 Recombinant Antibody

Catalog No.A2457 Purity:99%

Xentuzumab (Anti-IGF-1) is a recombinant a humanized monoclonal antibody that targets IGF ligands IGF-1 and IGF-2. Xentuzumab inhibits both of IGF-1 and IGF-2 growth-promoting signalling and suppresses AKT activation. MW: 145.5 KD.

Purity & Quality Control

Batch: Purity: 99% Protein concentration: 7.53mg/ml Endotoxin Level: ＜1EU/mg

Choose Selective IGF-1R Inhibitors

Name	Citation	IGF-1R	Insulin Receptor	Others
Linsitinib (OSI-906)	192	++	++	IRR
NVP-AEW541	64	+	++	FLT3,Tek,FLT1
GSK1904529A	26	+++	+++
NVP-ADW742	22	+
BMS-536924	24	++	++	FAK,MEK,LCK
AG-1024	27	+	+
GSK1838705A	18	++++	++++	ALK
BMS-754807	51	++++	++++	TrkB,Met,TrkA
PQ 401	3	+
Ginsenoside Rg5	0	++
XL228	0	++++		ABL T315I,LYN,Aurora A
Picropodophyllin (PPP)	41	++++
AZD3463	✔		ALK
S961		✔
Nordihydroguaiaretic acid (NDGA)	✔		p300,HER2,lipoxygenase

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Xentuzumab (Anti-IGF-1) is a recombinant a humanized monoclonal antibody that targets IGF ligands IGF-1 and IGF-2. Xentuzumab inhibits both of IGF-1 and IGF-2 growth-promoting signalling and suppresses AKT activation. MW: 145.5 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1417158-65-6
Molecular Weight	145.5 kDa
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100mMPro-Ac,20mMArg-Ac，pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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