Home Protein Tyrosine Kinase IGF-1R antagonist S961 For research use only.

S961

S961 is a biosynthetic insulin receptor antagonist that inhibits cellular proliferation and colony formation in breast tumour cells.

S961 Chemical Structure

S961 Chemical Structure

CAS No. 1083433-49-1

Purity & Quality Control

S961 Related Products

Signaling Pathway

IGF-1R Signaling Pathways

IGF-1R Signaling Pathway

Biological Activity

Description S961 is a biosynthetic insulin receptor antagonist that inhibits cellular proliferation and colony formation in breast tumour cells.
Targets
insulin receptor [1]
In vitro
In vitro

S961 is a biosynthetic insulin receptor (IR) antagonist that inhibits cellular proliferation.
Cell Research Cell lines MCF-7, MDA-MB-231 and T47D cells
Concentrations 10 nM
Incubation Time 2 h
Method

Cells were incubated with 1 or 10 nM of S961 for two hours, and then insulin was administered, and after 24 h, IC50 was measured.

Chemical Information & Solubility

Molecular Weight 4804.13 Formula

C211H297N55O71S2
CAS No. 1083433-49-1 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (20.81 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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