Home Transmembrane Transporters Sodium Channel inhibitor VX-150 For research use only.

VX-150

Synonyms: EOS-62073

VX-150 (EOS-62073) is an orally bioavailable pro-drug that rapidly converts into its active moiety, which is a highly selective inhibitor of NaV1.8 relative to the other sodium channel subtypes (>400-fold).

VX-150 Chemical Structure

VX-150 Chemical Structure

CAS No. 1793080-72-4

Purity & Quality Control

VX-150 Related Products

Signaling Pathway

Sodium Channel Signaling Pathways

Sodium Channel Signaling Pathway

Biological Activity

Description VX-150 (EOS-62073) is an orally bioavailable pro-drug that rapidly converts into its active moiety, which is a highly selective inhibitor of NaV1.8 relative to the other sodium channel subtypes (>400-fold).
Targets
NaV1.8 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03764072 Completed
Acute Pain
Vertex Pharmaceuticals Incorporated
 December 12 2018 Phase 2
NCT03206749 Completed
Acute Pain
Vertex Pharmaceuticals Incorporated
 June 29 2017 Phase 2
NCT02660424 Completed
Osteoarthritis
Vertex Pharmaceuticals Incorporated
 December 2015 Phase 2

Chemical Information & Solubility

Molecular Weight 516.34 Formula

C21H17F4N2O7P
CAS No. 1793080-72-4 SDF --
Smiles CC1=C(OC2=C(C=CC(=C2)C(F)(F)F)C(=O)NC3=CC(=O)N(CO[P](O)(O)=O)C=C3)C=CC(=C1)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (193.67 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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