Home Neuronal Signaling AChR agonist VU0357017 Hydrochloride For research use only.

VU0357017 Hydrochloride

Synonyms: CID-25010775

VU0357017 hydrochloride (CID-25010775) is a potent, highly selective and CNS-penetrant agonist of M1 which is a subtype of muscarinic acetylcholine receptors (mAChRs). VU0357017 hydrochloride appears to act at an allosteric site to activate the receptor with EC50 of 477 nM and Ki of 9.91 μM.

VU0357017 Hydrochloride Chemical Structure

VU0357017 Hydrochloride Chemical Structure

CAS No. 1135242-13-5

Purity & Quality Control

Batch: S679501 DMSO]38 mg/mL]false]Water]10 mg/mL]false]Ethanol]2 mg/mL]false Purity: 99.80%
99.80

VU0357017 Hydrochloride Related Products

Signaling Pathway

AChR Signaling Pathways

AChR Signaling Pathway

Biological Activity

Description VU0357017 hydrochloride (CID-25010775) is a potent, highly selective and CNS-penetrant agonist of M1 which is a subtype of muscarinic acetylcholine receptors (mAChRs). VU0357017 hydrochloride appears to act at an allosteric site to activate the receptor with EC50 of 477 nM and Ki of 9.91 μM.
Targets
M1 mAChR [1]
(Cell-free assay)		 M1 mAChR [1]
(Cell-free assay)
477 nM(EC50) 9.91 μM(Ki)

Chemical Information & Solubility

Molecular Weight 369.89 Formula

C18H28ClN3O3
CAS No. 1135242-13-5 SDF --
Smiles CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C.Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 38 mg/mL ( (102.73 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 10 mg/mL

Ethanol : 2 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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