Home Angiogenesis Bcr-Abl inhibitor Vodobatinib (K0706) For research use only.

Vodobatinib (K0706)

Synonyms: SCO-088, SUN K706, SUN-K0706

Vodobatinib (K0706, SCO-088, SUN K706, SUN-K0706) is a novel BCR-ABL1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants with IC50s of 167 nM, 154 nM,165 nM and 1967 nM for BCR-ABL1L248R, BCR-ABL1Y253H , BCR-ABL1E255V and BCR-ABL1T315I, respectively.

Vodobatinib (K0706) Chemical Structure

Vodobatinib (K0706) Chemical Structure

CAS No. 1388803-90-4

Purity & Quality Control

Batch: E004701 DMSO]91 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.71%
99.71

Vodobatinib (K0706) Related Products

Signaling Pathway

Bcr-Abl Signaling Pathways

Bcr-Abl Signaling Pathway

Biological Activity

Description Vodobatinib (K0706, SCO-088, SUN K706, SUN-K0706) is a novel BCR-ABL1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants with IC50s of 167 nM, 154 nM,165 nM and 1967 nM for BCR-ABL1L248R, BCR-ABL1Y253H , BCR-ABL1E255V and BCR-ABL1T315I, respectively.
Targets
BCR-ABL1 [1]
7 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03655236 Active not recruiting
Early Parkinson Disease
Sun Pharma Advanced Research Company Limited
 February 18 2019 Phase 2
NCT02629692 Active not recruiting
Healthy (For Part A)|Chronic Myeloid Leukemia (for Part B and C)
Sun Pharma Advanced Research Company Limited
 April 25 2017 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 453.92 Formula

C27H20ClN3O2
CAS No. 1388803-90-4 SDF --
Smiles CC1=C(C=C(C=C1)C(=O)NNC(=O)C2=C(C)C=CC=C2Cl)C#CC3=CC4=CC=CC=C4N=C3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 91 mg/mL ( (200.47 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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