Home Proteases HCV Protease inhibitor - COVID-19 inhibitor Velpatasvir For research use only.

Velpatasvir

Synonyms: GS-5816,VEL

Velpatasvir (GS-5816,VEL) is a second-generation NS5A inhibitor that inhibits hepatitis C viral replication through acting on the crucial "membranous web" that facilitates RNA replication.

Velpatasvir Chemical Structure

Velpatasvir Chemical Structure

CAS No. 1377049-84-7

Purity & Quality Control

Batch: S372401 DMSO]100 mg/mL]false]Water]100 mg/mL]false]Ethanol]100 mg/mL]false Purity: 99.66%
99.66

Velpatasvir Related Products

Signaling Pathway

HCV Protease Signaling Pathways

HCV Protease Signaling Pathway

Biological Activity

Description Velpatasvir (GS-5816,VEL) is a second-generation NS5A inhibitor that inhibits hepatitis C viral replication through acting on the crucial "membranous web" that facilitates RNA replication.
Targets
NS5A [1]
In vitro
In vitro

Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. It is a selective inhibitor of HCV RNA replication with mean 50% effective concentrations (EC50s) against GT1 to GT6 of 6 to 130 pM[2].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03520751 Suspended
Charcot-Marie-Tooth Neuropathy Type 1A
Nationwide Children''s Hospital
 April 2025 Phase 1|Phase 2
NCT05310565 Withdrawn
Colon Cancer Stage III|Colon Cancer Stage IV
Life University|University of Haifa
 January 1 2025 Not Applicable
NCT05145309 Not yet recruiting
Hypertension
University of Texas Southwestern Medical Center
 December 15 2024 Phase 2
NCT03866954 Withdrawn
Mitochondrial Diseases|Metabolic Disease|Inborn Errors of Metabolism
St George''s University of London|Neovii Biotech
 November 2024 Phase 2

Chemical Information & Solubility

Molecular Weight 883.00 Formula

C49H54N8O8
CAS No. 1377049-84-7 SDF Download Velpatasvir SDF
Smiles CC1CCC(N1C(=O)C(C(C)C)NC(=O)OC)C2=NC3=C(N2)C=CC4=CC5=C(C=C43)OCC6=C5C=CC(=C6)C7=CN=C(N7)C8CC(CN8C(=O)C(C9=CC=CC=C9)NC(=O)OC)COC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (113.25 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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