Home Metabolism PDE inhibitor Vardenafil dihydrochloride For research use only.

Vardenafil dihydrochloride

Vardenafil dihydrochloride is a potent, and selective inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. It also exhibits inhibition of PDE1 and PDE6 with IC50 of 180 nM and 11 nM respectively. It can be used for the research of erectile dysfunction, hepatitis, diabetes.

Vardenafil dihydrochloride Chemical Structure

Vardenafil dihydrochloride Chemical Structure

CAS: 224789-15-5

Purity & Quality Control

Batch: E484301 DMSO] 100 mg/mL] false] Water] 100 mg/mL] false] Ethanol] 25 mg/mL] false Purity: 99.84%
99.84

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Signaling Pathway

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Biological Activity

Description Vardenafil dihydrochloride is a potent, and selective inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. It also exhibits inhibition of PDE1 and PDE6 with IC50 of 180 nM and 11 nM respectively. It can be used for the research of erectile dysfunction, hepatitis, diabetes.

Chemical Information & Solubility

Molecular Weight 561.53 Formula

C23H32N6O4S.2ClH
CAS No. 224789-15-5 SDF Download Vardenafil dihydrochloride SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (178.08 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 25 mg/mL


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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