Home Ubiquitin DUB inhibitor USP25/28 inhibitor AZ1 For research use only.

USP25/28 inhibitor AZ1

AZ1 is a potent and noncompetitive dual Inhibitors of the ubiquitin-specific protease (USP) 25/28 with IC50s of 0.62 μM and 0.7 μM in Ub-RH110 assay,respectively.

USP25/28 inhibitor AZ1 Chemical Structure

USP25/28 inhibitor AZ1 Chemical Structure

CAS No. 2165322-94-9

Purity & Quality Control

USP25/28 inhibitor AZ1 Related Products

Signaling Pathway

DUB Signaling Pathways

DUB Signaling Pathway

Biological Activity

Description AZ1 is a potent and noncompetitive dual Inhibitors of the ubiquitin-specific protease (USP) 25/28 with IC50s of 0.62 μM and 0.7 μM in Ub-RH110 assay,respectively.
Targets
USP25 [1]
(Cell-free assay)		 USP28 [1]
(Cell-free assay)
0.62 μM 0.7 μM
In vitro
In vitro

AZ1 is able to reduce cell viability across a range of cancer cell lines with EC50 values typically clustered around 20 μM.[1]

Chemical Information & Solubility

Molecular Weight 422.21 Formula

C17H16BrF4NO2
CAS No. 2165322-94-9 SDF --
Smiles C1=CC(=C(C=C1COC2=C(C=C(C=C2)Br)CNCCO)C(F)(F)F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 84 mg/mL ( (198.95 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 84 mg/mL

Water : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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