Home DNA Damage/DNA Repair ATM/ATR inhibitor Tuvusertib For research use only.

Tuvusertib

Synonyms: M1774, ATR inhibitor 1

Tuvusertib (M1774, ATR inhibitor 1) is a potent ATR inhibitor, which exhibits anti-proliferative and anti-tumor effects in cancer cell lines.

Tuvusertib Chemical Structure

Tuvusertib Chemical Structure

CAS No. 1613200-51-3

Purity & Quality Control

Batch: E141101 DMSO]12 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.52%
99.52

Tuvusertib Related Products

Signaling Pathway

ATM/ATR Signaling Pathways

ATM/ATR Signaling Pathway

Biological Activity

Description Tuvusertib (M1774, ATR inhibitor 1) is a potent ATR inhibitor, which exhibits anti-proliferative and anti-tumor effects in cancer cell lines.
Targets
ATR [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06337630 Not yet recruiting
Solid Tumor
Institut Curie|ProLynx LLC|Merck Sharp & Dohme LLC
 June 15 2024 Phase 1
NCT06308263 Recruiting
Solid Tumor
Merck Healthcare KGaA Darmstadt Germany an affiliate of Merck KGaA Darmstadt Germany
 March 25 2024 Phase 1
NCT05396833 Recruiting
Metastatic or Locally Advanced Unresectable Solid Tumors
EMD Serono Research & Development Institute Inc.|Merck KGaA Darmstadt Germany|EMD Serono
 June 7 2022 Phase 1
NCT04170153 Active not recruiting
Metastatic or Locally Advanced Unresectable Solid Tumors
EMD Serono Research & Development Institute Inc.|Merck KGaA Darmstadt Germany|EMD Serono
 December 20 2019 Phase 1

Chemical Information & Solubility

Molecular Weight 370.32 Formula

C16H12F2N8O
CAS No. 1613200-51-3 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 12 mg/mL ( (32.4 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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