Home Metabolism THR activator T3 (Triiodothyronine) For research use only.

T3 (Triiodothyronine)

Synonyms: 3,3',5-Triiodo-L-thyronine

T3 (Triiodothyronine) is a thyroid hormone that affects various physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.This product is soluble but easy to precipitate after freezing in DMSO. 0.1 M NaOH is recommended as a stock solution.

T3 (Triiodothyronine) Chemical Structure

T3 (Triiodothyronine) Chemical Structure

CAS No. 6893-02-3

Purity & Quality Control

T3 (Triiodothyronine) Related Products

Biological Activity

Description T3 (Triiodothyronine) is a thyroid hormone that affects various physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.This product is soluble but easy to precipitate after freezing in DMSO. 0.1 M NaOH is recommended as a stock solution.
In vitro
In vitro

Triiodothyronine is one ingredient supplemented in the medium for inducing brown adipocytes differentiation.[1]
Cell Research Cell lines Brown preadipocytes
Concentrations 2 nM
Incubation Time 2 days
Method

Brown preadipocytes were isolated from perirenal adipose tissues of Chuanzhong black goats (1 day after birth). The cells were cultured in DMEM/F12 containing 10% fetal bovine serum and 2% penicillin/streptomycin and placed in an incubator (5% CO2, 37°C). Until 100% confluence, DMEM/F12 was supplemented with 2% FBS containing 5 μg/ml of insulin, 0.5 mM IBMX, and 2 nM triiodothyronine to induce brown adipocytes differentiation. Two days later, the induced medium was changed to a maintenance medium (DMEM/F12 supplemented with 2% FBS, 5 μg/ml of insulin, and 2 nM triiodothyronine). Cells were harvested 8 days after differentiation. L-carnitine was added to the medium throughout the differentiation process and supplemented at 600 μΜ. SiAMPKα (GAAGAGAAATTCAGAACCT)15 were transfected by Lipofectamine 3000. Lipid droplets were stained using Oil Red O solution. After staining, 1 ml isopropanol was used to dissolve the oil red O dye, and the absorbance at 510 nm was detected.

(Data sourced from selleck products)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06341517 Not yet recruiting
Schizophrenia; Psychosis
Indrit Begue|University of Geneva Switzerland
 November 5 2024 Not Applicable
NCT05333432 Not yet recruiting
Prostate Cancer
Assistance Publique - Hôpitaux de Paris|National Cancer Institute France
 June 1 2024 Not Applicable
NCT06323538 Not yet recruiting
Dietary Exposure|Diabetes Mellitus Type 2|Cardiovascular Diseases|Bone Loss|Sustainability|Exposure|Obesity|Vitamin Deficiency|Mineral Deficiency
German Federal Institute for Risk Assessment|Max Rubner-Institut|University of Bonn|Research Institute for Plant-Based Nutrition|University of Jena|University of Regensburg|Heidelberg University|University of Vienna
 April 1 2024 --
NCT06345924 Recruiting
Cancer|Palliative Care
University of Valencia
 March 1 2024 Not Applicable

Chemical Information & Solubility

Molecular Weight 650.97 Formula

C15H12I3NO4
CAS No. 6893-02-3 SDF --
Smiles C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)O)N)I)I)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (153.61 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

0.1M NAOH : 1.56 mg/mL

Water : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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