Home Metabolism PKM activator TP-1454 For research use only.

TP-1454

TP-1454 is an activator of PKM2 with AC50 of 10 Nm in biochemical assays.TP-1454 modulates tumor-immune responses by destabilizing T-regulatory cells.

TP-1454 Chemical Structure

TP-1454 Chemical Structure

CAS No. 2490276-04-3

Purity & Quality Control

Batch: E132801 DMSO]92 mg/mL]false]Ethanol]3 mg/mL]false]Water]Insoluble]false Purity: 99.08%
99.08

TP-1454 Related Products

Biological Activity

Description TP-1454 is an activator of PKM2 with AC50 of 10 Nm in biochemical assays.TP-1454 modulates tumor-immune responses by destabilizing T-regulatory cells.
Targets
PKM2 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04328740 Recruiting
Advanced Solid Tumor|Anal Cancer
Sumitomo Pharma America Inc.
 July 8 2020 Phase 1

Chemical Information & Solubility

Molecular Weight 462.46 Formula

C19H22F4N4O3S
CAS No. 2490276-04-3 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 92 mg/mL ( (198.93 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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