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Catalog No. Product Name Information Product Use Citations Product Validations
S8279 Shikonin Shikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.
Elife, 2024, 12RP91141
Elife, 2024, 12RP91141
Mol Ther Methods Clin Dev, 2024, 32(3):101307
S8616 PKM2 inhibitor(compound 3k) PKM2 inhibitor(Compound 3K, PKM2-IN-1) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
Elife, 2024, 12RP87674
Am J Cancer Res, 2024, 14(7):3468-3482
FASEB J, 2024, 38(11):e23702
S7928 DASA-58 DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
Cell Death Dis, 2023, 14(12):821
Int J Biol Sci, 2022, 18(16):6210-6225
Int J Mol Sci, 2022, 23(2)775
S7302 TEPP-46 (ML265) TEPP-46 (ML265, CID-44246499, NCGC00186528) is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL.
Environ Int, 2024, 191:108966
Cell Prolif, 2024, 57(2):e13548
J Clin Invest, 2023, 133(7)e166031
S6508 Mitapivat Mitapivat (AG-348) is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis.
Proc Natl Acad Sci U S A, 2022, 119(40):e2210779119
E1328 TP-1454 TP-1454 is an activator of PKM2 with AC50 of 10 Nm in biochemical assays.TP-1454 modulates tumor-immune responses by destabilizing T-regulatory cells.
E2829 Alkannin Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2), without inhibiting PKM1 and pyruvate kinase-L (PKL).
S5545 DL-Serine Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
S8279 Shikonin Shikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.
Elife, 2024, 12RP91141
Elife, 2024, 12RP91141
Mol Ther Methods Clin Dev, 2024, 32(3):101307
S8616 PKM2 inhibitor(compound 3k) PKM2 inhibitor(Compound 3K, PKM2-IN-1) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
Elife, 2024, 12RP87674
Am J Cancer Res, 2024, 14(7):3468-3482
FASEB J, 2024, 38(11):e23702
E2829 Alkannin Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2), without inhibiting PKM1 and pyruvate kinase-L (PKL).
S7928 DASA-58 DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
Cell Death Dis, 2023, 14(12):821
Int J Biol Sci, 2022, 18(16):6210-6225
Int J Mol Sci, 2022, 23(2)775
S7302 TEPP-46 (ML265) TEPP-46 (ML265, CID-44246499, NCGC00186528) is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL.
Environ Int, 2024, 191:108966
Cell Prolif, 2024, 57(2):e13548
J Clin Invest, 2023, 133(7)e166031
S6508 Mitapivat Mitapivat (AG-348) is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis.
Proc Natl Acad Sci U S A, 2022, 119(40):e2210779119
E1328 TP-1454 TP-1454 is an activator of PKM2 with AC50 of 10 Nm in biochemical assays.TP-1454 modulates tumor-immune responses by destabilizing T-regulatory cells.
S5545 DL-Serine Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.

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Tags: PKM activator | PKM inhibitor | PKM modulator |PKM activity