Home Metabolism THR inhibitor Tiratricol For research use only.

Tiratricol

Synonyms: triiodothyroacetic acid

Tiratricol (also known as TRIAC or triiodothyroacetic acid) is a thyroid hormone analogue.

Tiratricol Chemical Structure

Tiratricol Chemical Structure

CAS No. 51-24-1

Purity & Quality Control

Tiratricol Related Products

Biological Activity

Description Tiratricol (also known as TRIAC or triiodothyroacetic acid) is a thyroid hormone analogue.
In vitro
In vitro Tiratricol is indicated in the management of thyroid hormone resistance syndrome and is used, in combination with levothyroxine, to suppress thyroid-stimulating hormone production in patients with thyroid cancer. [1] It has been investigated for use in reducing goiter.[2] It has also shown some effectiveness in reducing the atrophy caused when using corticosteroids.[3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05579327 Recruiting
Monocarboxylate Transporter 8 Deficiency|Allan-Herndon-Dudley Syndrome
Rare Thyroid Therapeutics International AB|Premier Research Group plc|Egetis Therapeutics
 July 21 2023 Phase 3

Chemical Information & Solubility

Molecular Weight 621.93 Formula

C14H9I3O4
CAS No. 51-24-1 SDF Download Tiratricol SDF
Smiles C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(=O)O)I)I)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (160.78 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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