Home Angiogenesis Syk inhibitor - PI3K inhibitor - Epigenetic Reader Domain inhibitor SRX3207 For research use only.

SRX3207

SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity.

SRX3207 Chemical Structure

SRX3207 Chemical Structure

CAS No. 2254693-15-5

Purity & Quality Control

Batch: S894801 DMSO]33 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.76%
99.76

SRX3207 Related Products

Signaling Pathway

Syk Signaling Pathways

Syk Signaling Pathway

Biological Activity

Description SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity.
Targets
Syk [1]
(cell-free assay)		 PI3K alpha [1]
(cell-free assay)		 PI3K delta [1]
(cell-free assay)		 BRD41 [1]
(cell-free assay)		 BRD42 [1]
(cell-free assay)		 Click to View More Targets
39.9 nM 244 nM 388 nM 3070 nM 3070 nM
In Vivo
In vivo

SRX3207 blocks both PI3K and Syk in MΦs thereby activating innate and adaptive antitumor immunity in vivo.[1]
Animal Research Animal Models Floxed Syk mice, lysozyme M (LysM) Cre recombinase transgenic mice
Dosages 5 mg/kg, 15 mg/kg
Administration IV, PO

Chemical Information & Solubility

Molecular Weight 555.65 Formula

C29H29N7O3S

 
CAS No. 2254693-15-5 SDF --
Smiles CC1=NN(C=C1CN2CCC2)C3=NC(=NC=C3)NC4=CC=C(C=C4)C5=CSC6=C5OC(=CC6=O)N7CCOCC7
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 33 mg/mL ( (59.38 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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