SRX3207

Catalog No.S8948 Batch:S894801

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Technical Data

Formula

C29H29N7O3S

 
Molecular Weight 555.65 CAS No. 2254693-15-5
Solubility (25°C)* In vitro DMSO 33 mg/mL (59.38 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity.
Targets
Syk [1]
(cell-free assay)		 PI3K alpha [1]
(cell-free assay)		 PI3K delta [1]
(cell-free assay)		 BRD41 [1]
(cell-free assay)		 BRD42 [1]
(cell-free assay)		 View More
39.9 nM 244 nM 388 nM 3070 nM 3070 nM
In vivo

SRX3207 blocks both PI3K and Syk in MΦs thereby activating innate and adaptive antitumor immunity in vivo.[1]

Protocol (from reference)

Animal Study:

[1]
  • Animal Models

    Floxed Syk mice, lysozyme M (LysM) Cre recombinase transgenic mice

  • Dosages

    5 mg/kg, 15 mg/kg

  • Administration

    IV, PO

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.