Home MAPK Raf inhibitor - VEGFR inhibitor - PDGFR inhibitor - FLT3 inhibitor - Autophagy activator - Apoptosis related activator - Ferroptosis activator Sorafenib For research use only.

Sorafenib

Synonyms: NSC-724772,BAY 43-9006

Sorafenib is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-��, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.

Sorafenib Chemical Structure

Sorafenib Chemical Structure

CAS No. 284461-73-0

Purity & Quality Control

Sorafenib Related Products

Signaling Pathway

Raf Signaling Pathways

Raf Signaling Pathway

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 Growth Inhibition Assay IC50=0.00000303 ��M SANGER
MONO-MAC-6 Growth Inhibition Assay IC50=0.00418 ��M SANGER
ALL-PO Growth Inhibition Assay IC50=0.03184 ��M SANGER
NKM-1 Growth Inhibition Assay IC50=0.07416 ��M SANGER
CGTH-W-1 Growth Inhibition Assay IC50=0.25022 ��M SANGER
BB65-RCC Growth Inhibition Assay IC50=0.47073 ��M SANGER
NOS-1 Growth Inhibition Assay IC50=0.5636 ��M SANGER
SH-4 Growth Inhibition Assay IC50=0.65613 ��M SANGER
HOP-62 Growth Inhibition Assay IC50=0.85088 ��M SANGER
HCC2998 Growth Inhibition Assay IC50=0.88818 ��M SANGER
GDM-1 Growth Inhibition Assay IC50=0.90698 ��M SANGER
KM12 Growth Inhibition Assay IC50=1.02098 ��M SANGER
LB2518-MEL Growth Inhibition Assay IC50=1.20809 ��M SANGER
NCI-H1436 Growth Inhibition Assay IC50=1.21678 ��M SANGER
EM-2 Growth Inhibition Assay IC50=1.35578 ��M SANGER
LAMA-84 Growth Inhibition Assay IC50=1.37648 ��M SANGER
KG-1 Growth Inhibition Assay IC50=1.47935 ��M SANGER
A388 Growth Inhibition Assay IC50=1.59165 ��M SANGER
no-10 Growth Inhibition Assay IC50=1.61726 ��M SANGER
SF126 Growth Inhibition Assay IC50=1.63812 ��M SANGER
MEG-01 Growth Inhibition Assay IC50=1.8098 ��M SANGER
A3-KAW Growth Inhibition Assay IC50=1.8842 ��M SANGER
D-247MG Growth Inhibition Assay IC50=2.1448 ��M SANGER
OVCAR-4 Growth Inhibition Assay IC50=2.21393 ��M SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=2.3162 ��M SANGER
NCI-H2171 Growth Inhibition Assay IC50=2.39764 ��M SANGER
SIG-M5 Growth Inhibition Assay IC50=2.42242 ��M SANGER
BE-13 Growth Inhibition Assay IC50=2.69609 ��M SANGER
K052 Growth Inhibition Assay IC50=2.74616 ��M SANGER
L-540 Growth Inhibition Assay IC50=2.75789 ��M SANGER
KMOE-2 Growth Inhibition Assay IC50=2.8135 ��M SANGER
MFH-ino Growth Inhibition Assay IC50=2.92185 ��M SANGER
HL-60 Growth Inhibition Assay IC50=3.06299 ��M SANGER
HCC2218 Growth Inhibition Assay IC50=3.12003 ��M SANGER
TE-5 Growth Inhibition Assay IC50=3.13162 ��M SANGER
MZ1-PC Growth Inhibition Assay IC50=3.47509 ��M SANGER
MRK-nu-1 Growth Inhibition Assay IC50=3.61468 ��M SANGER
MZ7-mel Growth Inhibition Assay IC50=3.66099 ��M SANGER
BC-1 Growth Inhibition Assay IC50=3.7402 ��M SANGER
ST486 Growth Inhibition Assay IC50=3.83673 ��M SANGER
KS-1 Growth Inhibition Assay IC50=3.88198 ��M SANGER
SK-NEP-1 Growth Inhibition Assay IC50=4.16815 ��M SANGER
BC-3 Growth Inhibition Assay IC50=4.23391 ��M SANGER
NCI-H1581 Growth Inhibition Assay IC50=4.28798 ��M SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=4.40484 ��M SANGER
NOMO-1 Growth Inhibition Assay IC50=4.48905 ��M SANGER
QIMR-WIL Growth Inhibition Assay IC50=5.07294 ��M SANGER
SF539 Growth Inhibition Assay IC50=5.13227 ��M SANGER
TE-12 Growth Inhibition Assay IC50=5.24929 ��M SANGER
NCI-H510A Growth Inhibition Assay IC50=5.41685 ��M SANGER
JAR Growth Inhibition Assay IC50=5.50824 ��M SANGER
no-11 Growth Inhibition Assay IC50=5.73568 ��M SANGER
BV-173 Growth Inhibition Assay IC50=5.95682 ��M SANGER
SR Growth Inhibition Assay IC50=6.00678 ��M SANGER
MOLT-16 Growth Inhibition Assay IC50=6.25266 ��M SANGER
MZ2-MEL Growth Inhibition Assay IC50=6.31839 ��M SANGER
SW954 Growth Inhibition Assay IC50=6.45866 ��M SANGER
ML-2 Growth Inhibition Assay IC50=6.52849 ��M SANGER
OCI-AML2 Growth Inhibition Assay IC50=6.61062 ��M SANGER
SIMA Growth Inhibition Assay IC50=7.00101 ��M SANGER
DOHH-2 Growth Inhibition Assay IC50=7.05676 ��M SANGER
697 Growth Inhibition Assay IC50=7.05989 ��M SANGER
NB1 Growth Inhibition Assay IC50=7.40407 ��M SANGER
D-392MG Growth Inhibition Assay IC50=7.62663 ��M SANGER
ES8 Growth Inhibition Assay IC50=7.76503 ��M SANGER
RPMI-8226 Growth Inhibition Assay IC50=7.84511 ��M SANGER
IST-MEL1 Growth Inhibition Assay IC50=8.40002 ��M SANGER
NB14 Growth Inhibition Assay IC50=8.63133 ��M SANGER
HD-MY-Z Growth Inhibition Assay IC50=8.63746 ��M SANGER
TE-10 Growth Inhibition Assay IC50=8.76353 ��M SANGER
LC-1F Growth Inhibition Assay IC50=9.10834 ��M SANGER
OS-RC-2 Growth Inhibition Assay IC50=9.11243 ��M SANGER
NCI-SNU-16 Growth Inhibition Assay IC50=9.21026 ��M SANGER
SHP-77 Growth Inhibition Assay IC50=9.71662 ��M SANGER
A4-Fuk Growth Inhibition Assay IC50=9.7561 ��M SANGER
NB6 Growth Inhibition Assay IC50=9.76029 ��M SANGER
JiyoyeP-2003 Growth Inhibition Assay IC50=10.4745 ��M SANGER
DMS-114 Growth Inhibition Assay IC50=10.5441 ��M SANGER
NB7 Growth Inhibition Assay IC50=10.7526 ��M SANGER
NCI-H747 Growth Inhibition Assay IC50=11.1216 ��M SANGER
HH Growth Inhibition Assay IC50=11.3876 ��M SANGER
EW-18 Growth Inhibition Assay IC50=11.9044 ��M SANGER
CHP-126 Growth Inhibition Assay IC50=11.9738 ��M SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50=12.0278 ��M SANGER
DEL Growth Inhibition Assay IC50=12.0985 ��M SANGER
LU-139 Growth Inhibition Assay IC50=12.5413 ��M SANGER
P30-OHK Growth Inhibition Assay IC50=12.5479 ��M SANGER
NCI-H1522 Growth Inhibition Assay IC50=12.746 ��M SANGER
NCI-H1299 Growth Inhibition Assay IC50=13.2911 ��M SANGER
UACC-257 Growth Inhibition Assay IC50=13.5126 ��M SANGER
Calu-6 Growth Inhibition Assay IC50=13.6046 ��M SANGER
NCI-H1882 Growth Inhibition Assay IC50=13.8555 ��M SANGER
BB30-HNC Growth Inhibition Assay IC50=14.0609 ��M SANGER
ES1 Growth Inhibition Assay IC50=14.1551 ��M SANGER
NCI-H1694 Growth Inhibition Assay IC50=14.4811 ��M SANGER
IST-SL1 Growth Inhibition Assay IC50=14.9616 ��M SANGER
ECC4 Growth Inhibition Assay IC50=15.0558 ��M SANGER
MDA-MB-134-VI Growth Inhibition Assay IC50=15.4131 ��M SANGER
SCH Growth Inhibition Assay IC50=15.4728 ��M SANGER
SK-N-FI Growth Inhibition Assay IC50=15.6534 ��M SANGER
HDLM-2 Growth Inhibition Assay IC50=16.0714 ��M SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50=16.1297 ��M SANGER
EW-24 Growth Inhibition Assay IC50=16.1661 ��M SANGER
NCI-H2141 Growth Inhibition Assay IC50=16.189 ��M SANGER
LC4-1 Growth Inhibition Assay IC50=16.6119 ��M SANGER
HT-144 Growth Inhibition Assay IC50=17.006 ��M SANGER
SK-MEL-1 Growth Inhibition Assay IC50=17.0072 ��M SANGER
SCC-15 Growth Inhibition Assay IC50=17.1638 ��M SANGER
C8166 Growth Inhibition Assay IC50=17.6833 ��M SANGER
GOTO Growth Inhibition Assay IC50=17.8344 ��M SANGER
COR-L279 Growth Inhibition Assay IC50=18.1362 ��M SANGER
K-562 Growth Inhibition Assay IC50=18.7143 ��M SANGER
ES3 Growth Inhibition Assay IC50=18.8041 ��M SANGER
LU-165 Growth Inhibition Assay IC50=19.7008 ��M SANGER
KM-H2 Growth Inhibition Assay IC50=20.3184 ��M SANGER
RL Growth Inhibition Assay IC50=20.9692 ��M SANGER
EW-3 Growth Inhibition Assay IC50=21.1889 ��M SANGER
A101D Growth Inhibition Assay IC50=21.3752 ��M SANGER
HUTU-80 Growth Inhibition Assay IC50=21.3946 ��M SANGER
NCI-H23 Growth Inhibition Assay IC50=21.3992 ��M SANGER
PF-382 Growth Inhibition Assay IC50=21.4403 ��M SANGER
LB373-MEL-D Growth Inhibition Assay IC50=21.5615 ��M SANGER
TE-8 Growth Inhibition Assay IC50=21.6394 ��M SANGER
TE-9 Growth Inhibition Assay IC50=21.8513 ��M SANGER
Daudi Growth Inhibition Assay IC50=21.9304 ��M SANGER
D-542MG Growth Inhibition Assay IC50=22.0256 ��M SANGER
U-698-M Growth Inhibition Assay IC50=22.4603 ��M SANGER
ES6 Growth Inhibition Assay IC50=22.7366 ��M SANGER
DU-4475 Growth Inhibition Assay IC50=23.8897 ��M SANGER
ECC12 Growth Inhibition Assay IC50=24.2803 ��M SANGER
C2BBe1 Growth Inhibition Assay IC50=24.3239 ��M SANGER
IST-SL2 Growth Inhibition Assay IC50=24.4362 ��M SANGER
DJM-1 Growth Inhibition Assay IC50=24.5221 ��M SANGER
DMS-153 Growth Inhibition Assay IC50=24.8614 ��M SANGER
NB13 Growth Inhibition Assay IC50=25.0265 ��M SANGER
SK-N-DZ Growth Inhibition Assay IC50=26.3414 ��M SANGER
COR-L88 Growth Inhibition Assay IC50=26.5796 ��M SANGER
LU-65 Growth Inhibition Assay IC50=26.8535 ��M SANGER
TGBC1TKB Growth Inhibition Assay IC50=26.9828 ��M SANGER
THP-1 Growth Inhibition Assay IC50=27.2141 ��M SANGER
ONS-76 Growth Inhibition Assay IC50=27.332 ��M SANGER
LC-2-ad Growth Inhibition Assay IC50=27.6231 ��M SANGER
EW-13 Growth Inhibition Assay IC50=29.1746 ��M SANGER
MS-1 Growth Inhibition Assay IC50=30.7278 ��M SANGER
NCI-H2227 Growth Inhibition Assay IC50=30.9806 ��M SANGER
LXF-289 Growth Inhibition Assay IC50=31.4492 ��M SANGER
MC116 Growth Inhibition Assay IC50=32.0826 ��M SANGER
EVSA-T Growth Inhibition Assay IC50=32.2585 ��M SANGER
CTB-1 Growth Inhibition Assay IC50=33.1101 ��M SANGER
COLO-320-HSR Growth Inhibition Assay IC50=33.1603 ��M SANGER
NCI-H2196 Growth Inhibition Assay IC50=33.2557 ��M SANGER
LB2241-RCC Growth Inhibition Assay IC50=33.3135 ��M SANGER
LS-513 Growth Inhibition Assay IC50=33.8638 ��M SANGER
LP-1 Growth Inhibition Assay IC50=33.9956 ��M SANGER
A253 Growth Inhibition Assay IC50=34.2296 ��M SANGER
SK-MM-2 Growth Inhibition Assay IC50=34.9451 ��M SANGER
NCI-H1963 Growth Inhibition Assay IC50=35.3072 ��M SANGER
MMAC-SF Growth Inhibition Assay IC50=35.8785 ��M SANGER
LB831-BLC Growth Inhibition Assay IC50=36.0654 ��M SANGER
WSU-NHL Growth Inhibition Assay IC50=36.164 ��M SANGER
CESS Growth Inhibition Assay IC50=36.2848 ��M SANGER
NEC8 Growth Inhibition Assay IC50=36.5835 ��M SANGER
KNS-42 Growth Inhibition Assay IC50=37.1237 ��M SANGER
MHH-CALL-2 Growth Inhibition Assay IC50=37.1821 ��M SANGER
K5 Growth Inhibition Assay IC50=38.43 ��M SANGER
CP66-MEL Growth Inhibition Assay IC50=39.0733 ��M SANGER
OPM-2 Growth Inhibition Assay IC50=39.8432 ��M SANGER
IST-MES1 Growth Inhibition Assay IC50=40.3096 ��M SANGER
EC-GI-10 Growth Inhibition Assay IC50=41.5805 ��M SANGER
CTV-1 Growth Inhibition Assay IC50=42.8406 ��M SANGER
DG-75 Growth Inhibition Assay IC50=43.7595 ��M SANGER
KNS-81-FD Growth Inhibition Assay IC50=45.4058 ��M SANGER
NCI-H82 Growth Inhibition Assay IC50=45.5758 ��M SANGER
RPMI-8866 Growth Inhibition Assay IC50=46.1873 ��M SANGER
ACN Growth Inhibition Assay IC50=46.434 ��M SANGER
NCI-H1395 Growth Inhibition Assay IC50=46.4756 ��M SANGER
NCI-H209 Growth Inhibition Assay IC50=47.1405 ��M SANGER
TGW Growth Inhibition Assay IC50=49.0791 ��M SANGER
NCI-H748 Growth Inhibition Assay IC50=49.4753 ��M SANGER
EKVX Growth Inhibition Assay IC50=49.6628 ��M SANGER
MV4-11 Antiproliferative activity assay IC50 = 0.00087 ��M 19754199
MV4-11 Cytotoxicity assay IC50 = 0.00087 ��M 19654408
TT Antiproliferative activity assay IC50 = 0.0014 ��M 18849971
RS4-11 Function assay IC50 = 0.002 ��M 19654408
MOLM13 Function assay IC50 = 0.002 ��M 24641103
Sf9 Function assay IC50 = 0.003 ��M 21708468
RS4-11 Function assay IC50 = 0.0032 ��M 19654408
MV4-11 Growth inhibition assay IC50 = 0.004 ��M 29357250
A375 Function assay IC50 = 0.0044 ��M 29461827
MOLM13 Antiproliferative activity assay IC50 = 0.005 ��M 24641103
MV4-11 Function assay IC50 = 0.007 ��M 23362959
MV4-11 Cytotoxicity assay IC50 = 0.007 ��M 26342867
HEK293 Function assay Kd = 0.013 ��M 19754199
Kasumi-1 Antiproliferative activity assay IC50 = 0.015 ��M 20570526
MV4-11 Antiproliferative activity assay IC50 = 0.015 ��M 20570526
sf9 Function assay IC50 = 0.015 ��M 29266937
sf9 Function assay IC50 = 0.018 ��M 21708468
sf9 Function assay IC50 = 0.02 ��M 23618709
MV4-11 Antiproliferative activity assay GI50 = 0.03 ��M 21708468
Sf9 Function assay IC50 = 0.042 ��M 26081023
SF9 Function assay IC50 = 0.043 ��M 18473434
MV4-11 Cytotoxicity assay GI50 = 0.043 ��M 23618709
MV4-11 Function assay GI50 = 0.043 ��M 26081023
SF9 Function assay IC50 = 0.044 ��M 26081023
SF9 Function assay IC50 = 0.054 ��M 21708468
SF9 Function assay IC50 = 0.054 ��M 23618709
MOLM13 Antiproliferative activity assay GI50 = 0.056 ��M 21708468
MOLM13 Antiproliferative activity assay GI50 = 0.056 ��M 22726931
MOLM13 Cytotoxicity assay GI50 = 0.056 ��M 23618709
MOLM-13 Function assay GI50 = 0.056 ��M 26081023
SF9 Function assay IC50 = 0.058 ��M 29266937
WM266.4 Antiproliferative activity assay IC50 = 0.06 ��M 25496804
MDA-MB-231 Function assay IC50 = 0.063 ��M 28431342
SF9 Function assay IC50 = 0.09 ��M 29266937
Spodoptera frugiperda Function assay IC50 = 0.09 ��M 26922228
SF9 Function assay IC50 = 0.09 ��M 23562241
SF9 Function assay IC50 = 0.1 ��M 23442188
SF9 Function assay IC50 = 0.1 ��M 23442188
HEK293 Function assay IC50 = 0.12 ��M 26318998
MCF7 Antiproliferative activity assay IC50 = 0.19 ��M 25496804
MV4-11 Antiproliferative activity human IC50 = 0.3 ��M 28242553
HepG2 Antiproliferative activity assay EC50 = 0.302 ��M 27010810
THP1 Antiproliferative activity assay IC50 = 0.31 ��M 20570526
SMMC7721 Cytotoxicity assay IC50 = 0.37 ��M 25982075
HT-29 Antiproliferative activity assay IC50 = 0.39 ��M 25778995
sf9 Function assay Kd = 0.6 ��M 28109791
T47D Antiproliferative activity assay IC50 = 0.61 ��M 25778995
A549 Cytotoxicity assay IC50 = 0.63 ��M 25982075
HeLa Cytotoxicity assay IC50 = 0.64 ��M 30015070
WM3629 Antiproliferative activity assay GI50 = 0.65 ��M 20466542
SMMC7721 Antiproliferative activity assay IC50 = 0.65 ��M 26342134
WM3629 Growth inhibition assay GI50 = 0.78 ��M 20149658
WM3629 Antiproliferative activity assay GI50 = 0.78 ��M 26810260
MCF7 Antiproliferative activity assay IC50 = 0.78 ��M 25778995
K562 Antiproliferative activity assay IC50 = 0.86 ��M 24315192
COLO205 Antiproliferative activity assay IC50 = 0.87 ��M 25778995
T29 Cytotoxicity assay IC50 = 0.9 ��M 26318998
MDA-MB-231 Cytotoxicity assay IC50 = 0.94 ��M 25086238
MDA-MB-231 Cytotoxicity assay IC50 = 0.94 ��M 25440879
HepG2 Antiproliferative activity assay IC50 = 1.06 ��M 29628325
BL21(DE3) Function assay IC50 = 1.1 ��M 19928858
K562 Antiproliferative activity assay IC50 = 1.22 ��M 25778995
MDA-MB-231 Growth inhibition assay GI50 = 1.26 ��M 28088086
MDA-MB-231 Cytotoxicity assay GI50 = 1.26 ��M 26590508
MDA-MB-231 Antiproliferative activity assay GI50 = 1.26 ��M 27017549
SK-MEL-28 Antiproliferative activity assay EC50 = 1.3 ��M 18942827
sf9 Function assay Kd = 1.3 ��M 28109791
F-6-8 Cytotoxicity assay IC50 = 1.3 ��M 26318998
A549 Antiproliferative activity assay IC50 = 1.45 ��M 26342134
rhabdomyosarcoma Antiviral activity assay EC50 = 1.5 ��M 27288186
HL-60(TB) Growth inhibition assay GI50 = 1.58 ��M 28088086
RPMI8226 Growth inhibition assay GI50 = 1.58 ��M 28088086
KM12 Growth inhibition assay GI50 = 1.58 ��M 28088086
LOXIMVI Growth inhibition assay GI50 = 1.58 ��M 28088086
HCT116 Growth inhibition assay GI50 = 1.58 ��M 28088086
HOP92 Growth inhibition assay GI50 = 1.58 ��M 28088086
SF539 Growth inhibition assay GI50 = 1.58 ��M 28088086
UACC62 Growth inhibition assay GI50 = 1.58 ��M 28088086
SF295 Growth inhibition assay GI50 = 1.58 ��M 28088086
MDA-MB-435 Growth inhibition assay GI50 = 1.58 ��M 28088086
SK-MEL-5 Growth inhibition assay GI50 = 1.58 ��M 28088086
T47D Growth inhibition assay GI50 = 1.58 ��M 28088086
RPMI8266 Cytotoxicity assay GI50 = 1.58 ��M 26590508
HL-60(TB) Cytotoxicity assay GI50 = 1.58 ��M 26590508
KM12 Cytotoxicity assay GI50 = 1.58 ��M 26590508
HCT116 Cytotoxicity assay GI50 = 1.58 ��M 26590508
SF295 Cytotoxicity assay GI50 = 1.58 ��M 26590508
SF539 Cytotoxicity assay GI50 = 1.58 ��M 26590508
SK-MEL-2 Cytotoxicity assay GI50 = 1.58 ��M 26590508
MDA-MB-435 Cytotoxicity assay GI50 = 1.58 ��M 26590508
SK-MEL-5 Cytotoxicity assay GI50 = 1.58 ��M 26590508
LOXIMVI Cytotoxicity assay GI50 = 1.58 ��M 26590508
T47D Cytotoxicity assay GI50 = 1.58 ��M 26590508
SMMC7721 Antiproliferative activity assay IC50 = 1.58 ��M 26753815
LOXIMVI Antiproliferative activity assay GI50 = 1.58 ��M 27017549
UACC62 Antiproliferative activity assay GI50 = 1.58 ��M 27017549
SK-MEL-5 Antiproliferative activity assay GI50 = 1.58 ��M 27017549
KM12 Antiproliferative activity assay GI50 = 1.58 ��M 27017549
MDA-MB-435 Antiproliferative activity assay GI50 = 1.58 ��M 27017549
SF539 Antiproliferative activity assay GI50 = 1.58 ��M 27017549
SF295 Antiproliferative activity assay GI50 = 1.58 ��M 27017549
HCT116 Antiproliferative activity assay GI50 = 1.58 ��M 27017549
HOP92 Antiproliferative activity assay GI50 = 1.58 ��M 27017549
RPMI8226 Antiproliferative activity assay GI50 = 1.58 ��M 27017549
HL-60(TB) Antiproliferative activity assay GI50 = 1.58 ��M 27017549
T47D Antiproliferative activity assay GI50 = 1.58 ��M 27017549
7dF3 Function assay IC50 = 1.62 ��M 29266937
MDA-MB-435 Antiproliferative activity assay IC50 = 1.67 ��M 25778995
HL60 Cytotoxicity assay IC50 = 1.68 ��M 24858546
SW579 Antiproliferative activity human IC50 = 1.73 ��M 28242553
MCF7 Antiproliferative activity assay IC50 = 1.88 ��M 25637123
A375P Antiproliferative activity assay IC50 = 1.9 ��M 24128410
A549 Cytotoxicity assay IC50 = 1.92 ��M 24826815
HCT116 Antiproliferative activity assay IC50 = 2 ��M 22808911
MDA-MB-231 Cytotoxicity assay IC50 = 2 ��M 23454017
NCI-H23 Growth inhibition assay GI50 = 2 ��M 28088086
NCI-H522 Growth inhibition assay GI50 = 2 ��M 28088086
HOP62 Growth inhibition assay GI50 = 2 ��M 28088086
NCI-H226 Growth inhibition assay GI50 = 2 ��M 28088086
HT-29 Growth inhibition assay GI50 = 2 ��M 28088086
U251 Growth inhibition assay GI50 = 2 ��M 28088086
COLO205 Growth inhibition assay GI50 = 2 ��M 28088086
CCRF-CEM Growth inhibition assay GI50 = 2 ��M 28088086
MALME-3M Growth inhibition assay GI50 = 2 ��M 28088086
M14 Growth inhibition assay GI50 = 2 ��M 28088086
UACC257 Growth inhibition assay GI50 = 2 ��M 28088086
PC3 Growth inhibition assay GI50 = 2 ��M 28088086
SK-MEL-2 Growth inhibition assay GI50 = 2 ��M 28088086
MDA-MB-468 Growth inhibition assay GI50 = 2 ��M 28088086
CCRF-CEM Cytotoxicity assay GI50 = 2 ��M 26590508
NCI-H23 Cytotoxicity assay GI50 = 2 ��M 26590508
NCI-H522 Cytotoxicity assay GI50 = 2 ��M 26590508
COLO205 Cytotoxicity assay GI50 = 2 ��M 26590508
HT-29 Cytotoxicity assay GI50 = 2 ��M 26590508
SK-MEL-28 Cytotoxicity assay GI50 = 2 ��M 26590508
HOP62 Cytotoxicity assay GI50 = 2 ��M 26590508
UACC257 Cytotoxicity assay GI50 = 2 ��M 26590508
NCI-H226 Cytotoxicity assay GI50 = 2 ��M 26590508
U251 Cytotoxicity assay GI50 = 2 ��M 26590508
PC3 Cytotoxicity assay GI50 = 2 ��M 26590508
M14 Cytotoxicity assay GI50 = 2 ��M 26590508
MDA-MB-468 Cytotoxicity assay GI50 = 2 ��M 26590508
PC3 Antiproliferative activity assay GI50 = 2 ��M 27017549
MALME-3M Antiproliferative activity assay GI50 = 2 ��M 27017549
U251 Antiproliferative activity assay GI50 = 2 ��M 27017549
UACC257 Antiproliferative activity assay GI50 = 2 ��M 27017549
SK-MEL-2 Antiproliferative activity assay GI50 = 2 ��M 27017549
COLO205 Antiproliferative activity assay GI50 = 2 ��M 27017549
NCI-H23 Antiproliferative activity assay GI50 = 2 ��M 27017549
HT-29 Antiproliferative activity assay GI50 = 2 ��M 27017549
M14 Antiproliferative activity assay GI50 = 2 ��M 27017549
NCI-H226 Antiproliferative activity assay GI50 = 2 ��M 27017549
HOP62 Antiproliferative activity assay GI50 = 2 ��M 27017549
MDA-MB-468 Antiproliferative activity assay GI50 = 2 ��M 27017549
CCRF-CEM Antiproliferative activity assay GI50 = 2 ��M 27017549
NCI-H522 Antiproliferative activity assay GI50 = 2 ��M 27017549
A549 Antiproliferative activity assay IC50 = 2.02 ��M 26753815
MDA-MB-435 Growth inhibition assay IC50 = 2.11 ��M 29189002
NCI-H460 Antiproliferative activity assay IC50 = 2.19 ��M 30216849
H460 Cytotoxicity assay IC50 = 2.19 ��M 24826815
H460 Cytotoxicity assay IC50 = 2.19 ��M 25086238
H460 Cytotoxicity assay IC50 = 2.19 ��M 25440879
A375 Toxicity assay IC50 = 2.2 ��M 19654408
H460 Antiproliferative activity assay IC50 = 2.25 ��M 26991938
HCT116 Antiproliferative activity assay IC50 = 2.3 ��M 23260578
MKN45 Antiproliferative activity assay IC50 = 2.32 ��M 30216849
MKN45 Cytotoxicity assay IC50 = 2.32 ��M 24826815
MKN45 Cytotoxicity assay IC50 = 2.32 ��M 25086238
MKN45 Cytotoxicity assay IC50 = 2.32 ��M 25440879
U937 Antiproliferative activity assay GI50 = 2.34 ��M 29459144
A375 Antiproliferative activity assay IC50 = 2.4 ��M 22808911
HeLa Growth inhibition assay IC50 = 2.44 ��M 29102175
MDA-MB-231 Cytotoxicity assay IC50 = 2.5 ��M 22414612
MCF7 Antiproliferative activity assay IC50 = 2.51 ��M 30216849
UO31 Antiproliferative activity assay IC50 = 2.51 ��M 30216849
NCI-H322M Growth inhibition assay GI50 = 2.51 ��M 28088086
NCI-H460 Growth inhibition assay GI50 = 2.51 ��M 28088086
KM12 Growth inhibition assay TGI = 2.51 ��M 28088086
LOXIMVI Growth inhibition assay TGI = 2.51 ��M 28088086
EKVX Growth inhibition assay GI50 = 2.51 ��M 28088086
HCT116 Growth inhibition assay TGI = 2.51 ��M 28088086
SW620 Growth inhibition assay GI50 = 2.51 ��M 28088086
SF268 Growth inhibition assay GI50 = 2.51 ��M 28088086
SF539 Growth inhibition assay TGI = 2.51 ��M 28088086
A498 Growth inhibition assay GI50 = 2.51 ��M 28088086
UACC62 Growth inhibition assay TGI = 2.51 ��M 28088086
IGROV1 Growth inhibition assay GI50 = 2.51 ��M 28088086
HCT15 Growth inhibition assay GI50 = 2.51 ��M 28088086
SK-MEL-28 Growth inhibition assay GI50 = 2.51 ��M 28088086
SK-MEL-28 Growth inhibition assay TGI = 2.51 ��M 28088086
ACHN Growth inhibition assay GI50 = 2.51 ��M 28088086
SK-MEL-5 Growth inhibition assay TGI = 2.51 ��M 28088086
NCI/ADR-RES Growth inhibition assay GI50 = 2.51 ��M 28088086
MCF7 Growth inhibition assay GI50 = 2.51 ��M 28088086
SN12C Growth inhibition assay GI50 = 2.51 ��M 28088086
Hs 578T Growth inhibition assay GI50 = 2.51 ��M 28088086
SKOV3 Growth inhibition assay GI50 = 2.51 ��M 28088086
UO31 Growth inhibition assay GI50 = 2.51 ��M 28088086
NCI-H460 Cytotoxicity assay GI50 = 2.51 ��M 26590508
HCT15 Cytotoxicity assay GI50 = 2.51 ��M 26590508
SW620 Cytotoxicity assay GI50 = 2.51 ��M 26590508
SF268 Cytotoxicity assay GI50 = 2.51 ��M 26590508
IGROV1 Cytotoxicity assay GI50 = 2.51 ��M 26590508
OVCAR8 Cytotoxicity assay GI50 = 2.51 ��M 26590508
NCI/ADR-RES Cytotoxicity assay GI50 = 2.51 ��M 26590508
SKOV3 Cytotoxicity assay GI50 = 2.51 ��M 26590508
SN12C Cytotoxicity assay GI50 = 2.51 ��M 26590508
NCI-H322M Cytotoxicity assay GI50 = 2.51 ��M 26590508
MCF7 Cytotoxicity assay GI50 = 2.51 ��M 26590508
UO31 Cytotoxicity assay GI50 = 2.51 ��M 26590508
Hs578T Cytotoxicity assay GI50 = 2.51 ��M 26590508
A498 Cytotoxicity assay GI50 = 2.51 ��M 26590508
A498 Antiproliferative activity assay GI50 = 2.51 ��M 27017549
SKOV3 Antiproliferative activity assay GI50 = 2.51 ��M 27017549
UO31 Antiproliferative activity assay GI50 = 2.51 ��M 27017549
NCI-ADR-RES Antiproliferative activity assay GI50 = 2.51 ��M 27017549
SN12C Antiproliferative activity assay GI50 = 2.51 ��M 27017549
IGROV1 Antiproliferative activity assay GI50 = 2.51 ��M 27017549
ACHN Antiproliferative activity assay GI50 = 2.51 ��M 27017549
OVCAR8 Antiproliferative activity assay GI50 = 2.51 ��M 27017549
SK-MEL-28 Antiproliferative activity assay GI50 = 2.51 ��M 27017549
NCI-H322M Antiproliferative activity assay GI50 = 2.51 ��M 27017549
SF268 Antiproliferative activity assay GI50 = 2.51 ��M 27017549
HCT15 Antiproliferative activity assay GI50 = 2.51 ��M 27017549
NCI-H460 Antiproliferative activity assay GI50 = 2.51 ��M 27017549
SW620 Antiproliferative activity assay GI50 = 2.51 ��M 27017549
EKVX Antiproliferative activity assay GI50 = 2.51 ��M 27017549
MCF7 Antiproliferative activity assay GI50 = 2.51 ��M 27017549
Hs 578T Antiproliferative activity assay GI50 = 2.51 ��M 27017549
HT-29 Antiproliferative activity assay IC50 = 2.58 ��M 29886324
A375P Antiproliferative activity assay GI50 = 2.58 ��M 26810260
TPC1 Antiproliferative activity assay EC50 = 2.6 ��M 22559926
Hep3B Growth inhibition assay IC50 = 2.63 ��M 29102175
A375P Antiproliferative activity assay IC50 = 2.7 ��M 22460030
U937 Antiproliferative activity assay GI50 = 2.74 ��M 26318067
U937 Cytotoxicity assay GI50 = 2.74 ��M 24878193
MCF7 Growth inhibition assay IC50 = 2.78 ��M 29102175
MDA-MB-231 Antiproliferative activity assay IC50 = 2.8 ��M 29202403
HepG2 Antiproliferative activity assay IC50 = 2.84 ��M 28242553
U937 Growth inhibition assay GI50 = 2.85 ��M 22014755
A549 Cytotoxicity assay IC50 = 2.92 ��M 28927801
A549 Cytotoxicity assay IC50 = 2.92 ��M 27777009
ZR75-30 Growth inhibition assay IC50 = 2.96 ��M 29102175
PC3 Cytotoxicity assay IC50 = 3.03 ��M 28340913
MDA-MB-231 Antiproliferative activity assay IC50 = 3.08 ��M 26991938
A549 Growth inhibition assay IC50 = 3.1 ��M 29102175
K562 Growth inhibition assay GI50 = 3.16 ��M 28088086
MOLT4 Growth inhibition assay GI50 = 3.16 ��M 28088086
A549/ATCC Growth inhibition assay GI50 = 3.16 ��M 28088086
RPMI8226 Growth inhibition assay TGI = 3.16 ��M 28088086
SR Growth inhibition assay GI50 = 3.16 ��M 28088086
HOP62 Growth inhibition assay TGI = 3.16 ��M 28088086
NCI-H226 Growth inhibition assay TGI = 3.16 ��M 28088086
U251 Growth inhibition assay TGI = 3.16 ��M 28088086
COLO205 Growth inhibition assay TGI = 3.16 ��M 28088086
M14 Growth inhibition assay TGI = 3.16 ��M 28088086
HCC2998 Growth inhibition assay GI50 = 3.16 ��M 28088086
SNB75 Growth inhibition assay GI50 = 3.16 ��M 28088086
786-0 Growth inhibition assay GI50 = 3.16 ��M 28088086
A498 Growth inhibition assay TGI = 3.16 ��M 28088086
HCT15 Growth inhibition assay TGI = 3.16 ��M 28088086
OVCAR3 Growth inhibition assay GI50 = 3.16 ��M 28088086
OVCAR4 Growth inhibition assay GI50 = 3.16 ��M 28088086
Caki1 Growth inhibition assay GI50 = 3.16 ��M 28088086
SNB19 Growth inhibition assay GI50 = 3.16 ��M 28088086
OVCAR5 Growth inhibition assay GI50 = 3.16 ��M 28088086
DU145 Growth inhibition assay GI50 = 3.16 ��M 28088086
OVCAR8 Growth inhibition assay GI50 = 3.16 ��M 28088086
SN12C Growth inhibition assay TGI = 3.16 ��M 28088086
MDA-MB-231 Growth inhibition assay TGI = 3.16 ��M 28088086
RXF393 Growth inhibition assay GI50 = 3.16 ��M 28088086
BT549 Growth inhibition assay GI50 = 3.16 ��M 28088086
K562 Cytotoxicity assay GI50 = 3.16 ��M 26590508
MOLT4 Cytotoxicity assay GI50 = 3.16 ��M 26590508
SNB19 Cytotoxicity assay GI50 = 3.16 ��M 26590508
SR Cytotoxicity assay GI50 = 3.16 ��M 26590508
A549 Cytotoxicity assay GI50 = 3.16 ��M 26590508
OVCAR3 Cytotoxicity assay GI50 = 3.16 ��M 26590508
OVCAR4 Cytotoxicity assay GI50 = 3.16 ��M 26590508
SNB75 Cytotoxicity assay GI50 = 3.16 ��M 26590508
OVCAR5 Cytotoxicity assay GI50 = 3.16 ��M 26590508
DU145 Cytotoxicity assay GI50 = 3.16 ��M 26590508
786-0 Cytotoxicity assay GI50 = 3.16 ��M 26590508
BT549 Cytotoxicity assay GI50 = 3.16 ��M 26590508
ACHN Cytotoxicity assay GI50 = 3.16 ��M 26590508
Caki1 Cytotoxicity assay GI50 = 3.16 ��M 26590508
786-0 Antiproliferative activity assay GI50 = 3.16 ��M 27017549
LOXIMVI Antiproliferative activity assay TGI = 3.16 ��M 27017549
Caki1 Antiproliferative activity assay GI50 = 3.16 ��M 27017549
OVCAR5 Antiproliferative activity assay GI50 = 3.16 ��M 27017549
RXF393 Antiproliferative activity assay GI50 = 3.16 ��M 27017549
SNB75 Antiproliferative activity assay GI50 = 3.16 ��M 27017549
OVCAR3 Antiproliferative activity assay GI50 = 3.16 ��M 27017549
SNB19 Antiproliferative activity assay GI50 = 3.16 ��M 27017549
SK-MEL-5 Antiproliferative activity assay TGI = 3.16 ��M 27017549
OVCAR4 Antiproliferative activity assay GI50 = 3.16 ��M 27017549
SK-MEL-2 Antiproliferative activity assay TGI = 3.16 ��M 27017549
BT549 Antiproliferative activity assay GI50 = 3.16 ��M 27017549
MOLT4 Antiproliferative activity assay GI50 = 3.16 ��M 27017549
K562 Antiproliferative activity assay GI50 = 3.16 ��M 27017549
HCC2998 Antiproliferative activity assay GI50 = 3.16 ��M 27017549
HCC2998 Antiproliferative activity assay TGI = 3.16 ��M 27017549
A549/ATCC Antiproliferative activity assay GI50 = 3.16 ��M 27017549
DU145 Antiproliferative activity assay GI50 = 3.16 ��M 27017549
SR Antiproliferative activity assay GI50 = 3.16 ��M 27017549
MCF7 Cytotoxicity assay IC50 = 3.18 ��M 28927801
PC3 Cytotoxicity assay IC50 = 3.18 ��M 28927801
MCF7 Cytotoxicity assay IC50 = 3.18 ��M 27777009
A549 Antiproliferative activity assay IC50 = 3.19 ��M 25778995
PC3 Cytotoxicity assay IC50 = 3.24 ��M 27777009
HeLa Function assay IC50 = 3.3 ��M 15225706
HeLa Function assay IC50 = 3.3 ��M 15225706
LoVo Cytotoxicity assay IC50 = 3.3 ��M 23454017
A375 Antiproliferative activity assay IC50 = 3.36 ��M 29602674
HT-29 Antiproliferative activity assay IC50 = 3.37 ��M 26991938
FLT3 gene-deficient U937 Antiproliferative activity assay GI50 = 3.4 ��M 21708468
FLT3 negative U937 Cytotoxicity assay GI50 = 3.4 ��M 23618709
U937 Cytotoxicity assay GI50 = 3.4 ��M 26081023
A375P Antiproliferative activity assay GI50 = 3.4 ��M 29459144
ACHN Cytotoxicity assay IC50 = 3.4 ��M 29517908
ACHN Cytotoxicity assay IC50 = 3.4 ��M 29297688
HepG2 Function assay IC50 = 3.4 ��M 26071861
A375P Cytotoxicity assay GI50 = 3.4 ��M 24878193
HepG2 Cytotoxicity assay IC50 = 3.44 ��M 28927801
HepG2 Cytotoxicity assay IC50 = 3.44 ��M 27777009
ACHN Cytotoxicity assay IC50 = 3.5 ��M 29786436
HepG2 Antiproliferative activity assay IC50 = 3.5 ��M 25462265
HT-29 Cytotoxicity assay IC50 = 3.61 ��M 24826815
HT-29 Antiproliferative activity assay IC50 = 3.61 ��M 30216849
HT-29 Cytotoxicity assay IC50 = 3.61 ��M 25086238
HT-29 Cytotoxicity assay IC50 = 3.61 ��M 25440879
MCF7 Anticancer activity assay IC50 = 3.64 ��M 29549841
Sf9 Function assay IC50 = 3.8 ��M 21708468
Sf9 Function assay IC50 = 3.8 ��M 23618709
Sf9 Function assay IC50 = 3.8 ��M 26081023
A2058 Cytotoxicity assay IC50 = 3.8 ��M 22708987
NCI-H460 Cytotoxicity assay IC50 = 3.9 ��M 23454017
SK-MEL-30 Cytotoxicity assay IC50 = 3.9 ��M 29461827
HT-29 Anticancer activity assay IC50 = 3.97 ��M 29549841
SF268 Growth inhibition assay TGI = 3.98 ��M 28088086
SNB75 Growth inhibition assay TGI = 3.98 ��M 28088086
OVCAR3 Growth inhibition assay TGI = 3.98 ��M 28088086
SNB19 Growth inhibition assay TGI = 3.98 ��M 28088086
Hs 578T Growth inhibition assay TGI = 3.98 ��M 28088086
TK10 Growth inhibition assay GI50 = 3.98 ��M 28088086
BT549 Growth inhibition assay TGI = 3.98 ��M 28088086
Caki1 Antiproliferative activity assay TGI = 3.98 ��M 27017549
TK10 Antiproliferative activity assay GI50 = 3.98 ��M 27017549
MDA-MB-435 Antiproliferative activity assay TGI = 3.98 ��M 27017549
HCT116 Antiproliferative activity assay TGI = 3.98 ��M 27017549
MDA-MB-231 Antiproliferative activity assay TGI = 3.98 ��M 27017549
HepG2 Cytotoxicity assay IC50 = 4 ��M 23454017
HT-29 Cytotoxicity assay IC50 = 4 ��M 23454017
A549 Cytotoxicity assay IC50 = 4 ��M 23454017
HuH7 Cytotoxicity assay GI50 = 4 ��M 23726028
PC3 Antiproliferative activity assay IC50 = 4.13 ��M 25778995
HeLa Cytotoxicity assay IC50 = 4.163 ��M 23362959
MDA-MB-436 Antiproliferative activity assay IC50 = 4.2 ��M 29202403
MCF7 Cytotoxicity assay IC50 = 4.21 ��M 27043268
MCF7 Cytotoxicity assay IC50 = 4.21 ��M 28340913
LOXIMVI Antiproliferative activity assay IC50 = 4.25 ��M 25778995
OVCAR4 Cytotoxicity assay TGI = 4.31 ��M 26590508
WM1361 Antiproliferative activity assay GI50 = 4.345 ��M 20148563
WM266.4 Growth inhibition assay GI50 = 4.5 ��M 20199087
HepG2 Cytotoxicity assay GI50 = 4.5 ��M 23726028
A549 Antiproliferative activity assay IC50 = 4.5 ��M 23260578
LS174T Function assay IC50 = 4.52 ��M 29266937
8505C Antiproliferative activity assay IC50 = 4.7 ��M 29032031
OVCAR8 Cytotoxicity assay TGI = 4.73 ��M 26590508
MDA-MB-231 Cytotoxicity assay IC50 = 4.77 ��M 20435479
B16-F1 Antiproliferative activity assay IC50 = 4.9 ��M 18477505
WM164 Antiproliferative activity assay IC50 = 4.9 ��M 17561392
B16-F1 Antiproliferative activity assay IC50 = 4.9 ��M 20056548
MDA-MB-468 Cytotoxicity assay IC50 = 4.9 ��M 26159483
786-O Cytotoxicity assay IC50 = 4.9 ��M 29517908
786-O Cytotoxicity assay IC50 = 4.9 ��M 29297688
WM266.4 Antiproliferative activity assay GI50 = 4.933 ��M 20148563
WM266.4 Growth inhibition assay IC50 = 5 ��M 19323560
WM164 Antiproliferative activity assay IC50 = 5 ��M 20056548
HepG2 Antiproliferative activity assay IC50 = 5 ��M 23260578
HepG2 Antiproliferative activity assay IC50 = 5 ��M 23932071
NCI-H23 Growth inhibition assay TGI = 5.01 ��M 28088086
NCI-H322M Growth inhibition assay TGI = 5.01 ��M 28088086
NCI-H460 Growth inhibition assay TGI = 5.01 ��M 28088086
NCI-H522 Growth inhibition assay TGI = 5.01 ��M 28088086
HT-29 Growth inhibition assay TGI = 5.01 ��M 28088086
CCRF-CEM Growth inhibition assay TGI = 5.01 ��M 28088086
SW620 Growth inhibition assay TGI = 5.01 ��M 28088086
HOP92 Growth inhibition assay TGI = 5.01 ��M 28088086
786-0 Growth inhibition assay TGI = 5.01 ��M 28088086
MDA-MB-435 Growth inhibition assay TGI = 5.01 ��M 28088086
PC3 Growth inhibition assay TGI = 5.01 ��M 28088086
UACC257 Growth inhibition assay TGI = 5.01 ��M 28088086
SKOV3 Growth inhibition assay TGI = 5.01 ��M 28088086
RXF393 Growth inhibition assay TGI = 5.01 ��M 28088086
T47D Growth inhibition assay TGI = 5.01 ��M 28088086
MDA-MB-468 Growth inhibition assay TGI = 5.01 ��M 28088086
UACC62 Antiproliferative activity assay TGI = 5.01 ��M 27017549
UACC257 Antiproliferative activity assay TGI = 5.01 ��M 27017549
SK-MEL-5 Antiproliferative activity assay LC50 = 5.01 ��M 27017549
M14 Antiproliferative activity assay TGI = 5.01 ��M 27017549
NCI-H23 Antiproliferative activity assay TGI = 5.01 ��M 27017549
SF295 Antiproliferative activity assay TGI = 5.01 ��M 27017549
HOP92 Antiproliferative activity assay TGI = 5.01 ��M 27017549
BT549 Antiproliferative activity assay TGI = 5.01 ��M 27017549
MDA-MB-231 Cytotoxicity assay IC50 = 5.1 ��M 26159483
DU145 Cytotoxicity assay IC50 = 5.1 ��M 22708987
A549 Cytotoxicity assay IC50 = 5.21 ��M 20181414
HeLa Cytotoxicity assay IC50 = 5.23 ��M 26342867
786-O Cytotoxicity assay IC50 = 5.3 ��M 29786436
HCT116 Antiproliferative activity assay GI50 = 5.4 ��M 15225706
A375 Antiproliferative activity assay IC50 = 5.4 ��M 18477505
SK-MEL-188 Antiproliferative activity assay IC50 = 5.4 ��M 17561392
A375 Antiproliferative activity assay IC50 = 5.4 ��M 20056548
MCF7 Cytotoxicity assay IC50 = 5.5 ��M 26159483
A375 Antiproliferative activity assay IC50 = 5.58 ��M 19464887
A375P Cytotoxicity assay IC50 = 5.58 ��M 20797858
A375P Antiproliferative activity assay GI50 = 5.58 ��M 21353571
A375P Growth inhibition assay GI50 = 5.58 ��M 22014755
A375P Growth inhibition assay GI50 = 5.58 ��M 20149658
A375P Antiproliferative activity assay GI50 = 5.58 ��M 20466542
A375P Antiproliferative activity assay IC50 = 5.6 ��M 19857963
A375P Antiproliferative activity assay IC50 = 5.6 ��M 21592628
A375P Antiproliferative activity assay IC50 = 5.6 ��M 22033063
A375P Cytotoxicity assay IC50 = 5.6 ��M 19897366
A375P Antiproliferative activity assay IC50 = 5.6 ��M 22647720
HCT116 Cytotoxicity assay IC50 = 5.65 ��M 24215818
SH-SY5Y Antiproliferative activity assay IC50 = 5.73 ��M 24315192
HepG2 Cytotoxicity assay IC50 = 5.74 ��M 25461318
Bel7402 Cytotoxicity assay IC50 = 5.8 ��M 23454017
HT-29 Cytotoxicity assay IC50 = 5.9 ��M 28865276
melanoma Growth inhibition assay IC50 = 6.1 ��M 16392826
K562 Antiproliferative activity assay GI50 = 6.2 ��M 21708468
HepG2 Cytotoxicity assay IC50 = 6.2 ��M 28865276
A549 Anticancer activity assay IC50 = 6.21 ��M 29549841
SMMC7721 Antiproliferative activity assay IC50 = 6.23 ��M 22721924
HepG2 Antiproliferative activity assay IC50 = 6.3 ��M 23932071
SF295 Growth inhibition assay TGI = 6.31 ��M 28088086
SK-MEL-2 Growth inhibition assay TGI = 6.31 ��M 28088086
OVCAR5 Growth inhibition assay TGI = 6.31 ��M 28088086
UO31 Growth inhibition assay TGI = 6.31 ��M 28088086
A498 Antiproliferative activity assay TGI = 6.31 ��M 27017549
MALME-3M Antiproliferative activity assay TGI = 6.31 ��M 27017549
U251 Antiproliferative activity assay TGI = 6.31 ��M 27017549
SK-MEL-2 Antiproliferative activity assay LC50 = 6.31 ��M 27017549
RPMI8226 Antiproliferative activity assay TGI = 6.31 ��M 27017549
HCC2998 Antiproliferative activity assay LC50 = 6.31 ��M 27017549
NCI-H522 Antiproliferative activity assay TGI = 6.31 ��M 27017549
HUVEC Antiproliferative activity assay IC50 = 6.42 ��M 23644219
A549 Cytotoxicity assay IC50 = 6.53 ��M 27043268
A549 Cytotoxicity assay IC50 = 6.53 ��M 28340913
LoVo Antiproliferative activity assay IC50 = 6.56 ��M 24315192
A375 Function assay IC50 = 6.599 ��M 21807507
HCT116 Function assay GI50 = 6.6 ��M 15225706
HepG2 Cytotoxicity assay IC50 = 6.7 ��M 26159483
BCPAP Antiproliferative activity assay IC50 = 6.7 ��M 29032031
A549 Cytotoxicity assay IC50 = 6.7 ��M 28865276
PC3 Cytotoxicity assay IC50 = 6.8 ��M 23021967
SGC7901 Cytotoxicity assay IC50 = 6.9 ��M 23454017
OS-RC2 Cytotoxicity assay IC50 = 7 ��M 29517908
OS-RC2 Cytotoxicity assay IC50 = 7 ��M 29297688
COLO205 Antiproliferative activity human IC50 = 7.04 ��M 28242553
rhabdomyosarcoma Cytotoxicity activity against human CC50 = 7.05 ��M 27288186
HuH7 Cytotoxicity assay IC50 = 7.1 ��M 26159483
MDA-MB-231 Antiproliferative activity assay IC50 = 7.18 ��M 22721924
FLT3-negative K562 Cytotoxicity assay GI50 = 7.3 ��M 23618709
K562 Function assay GI50 = 7.3 ��M 26081023
K562 Function assay GI50 = 7.3 ��M 26081023
MCF7 Antiproliferative activity assay IC50 = 7.33 ��M 23644219
A549 Cytotoxicity assay TGI = 7.36 ��M 26590508
WI38 Cytotoxicity assay IC50 = 7.54 ��M 24826815
A375 Cytotoxicity assay IC50 = 7.56 ��M 24215818
MDA-MB-231 Cytotoxicity assay IC50 = 7.62 ��M 20181414
786-0 Cytotoxicity assay TGI = 7.62 ��M 26590508
HS27 Antiproliferative activity assay IC50 = 7.8 ��M 19857963
HS27 Cytotoxicity assay IC50 = 7.8 ��M 19897366
HCT116 Cytotoxicity assay IC50 = 7.8 ��M 22483592
HS27 Antiproliferative activity assay IC50 = 7.85 ��M 19464887
HS27 Antiproliferative activity assay GI50 = 7.85 ��M 21353571
A549/ATCC Growth inhibition assay TGI = 7.94 ��M 28088086
DU145 Growth inhibition assay TGI = 7.94 ��M 28088086
NCI/ADR-RES Growth inhibition assay TGI = 7.94 ��M 28088086
MCF7 Growth inhibition assay TGI = 7.94 ��M 28088086
PC3 Antiproliferative activity assay TGI = 7.94 ��M 27017549
UO31 Antiproliferative activity assay TGI = 7.94 ��M 27017549
NCI-ADR-RES Antiproliferative activity assay TGI = 7.94 ��M 27017549
LOXIMVI Antiproliferative activity assay LC50 = 7.94 ��M 27017549
SK-MEL-28 Antiproliferative activity assay TGI = 7.94 ��M 27017549
KM12 Antiproliferative activity assay TGI = 7.94 ��M 27017549
COLO205 Antiproliferative activity assay TGI = 7.94 ��M 27017549
HT-29 Antiproliferative activity assay TGI = 7.94 ��M 27017549
NCI-H226 Antiproliferative activity assay TGI = 7.94 ��M 27017549
HOP62 Antiproliferative activity assay TGI = 7.94 ��M 27017549
T47D Antiproliferative activity assay TGI = 7.94 ��M 27017549
MDA-MB-468 Antiproliferative activity assay TGI = 7.94 ��M 27017549
EKVX Antiproliferative activity assay TGI = 7.94 ��M 27017549
MCF7 Antiproliferative activity assay TGI = 7.94 ��M 27017549
Hs 578T Antiproliferative activity assay TGI = 7.94 ��M 27017549
MGC803 Antiproliferative activity assay IC50 = 7.99 ��M 26560049
HCT116 Antiproliferative activity assay IC50 = 8.08 ��M 24440479
PC3 Cytotoxicity assay IC50 = 8.08 ��M 27043268
HCT116 Antiproliferative activity assay IC50 = 8.08 ��M 23644219
WM266.4 Antiproliferative activity assay GI50 = 8.1 ��M 23025996
WM266.4 Antiproliferative activity assay GI50 = 8.12 ��M 22583669
Ketr3 Antiproliferative activity assay IC50 = 8.27 ��M 30216849
A375 Antiproliferative activity assay IC50 = 8.27 ��M 30216849
HepG2 Antiproliferative activity assay IC50 = 8.27 ��M 30216849
MX1 Antiproliferative activity assay IC50 = 8.27 ��M 30216849
MX1 Cytotoxicity assay IC50 = 8.27 ��M 24675135
WM266.4 Growth inhibition assay GI50 = 8.3 ��M 22361686
PLC/PRF/5 Cytotoxicity assay IC50 = 8.3 ��M 21531053
A375 Antiproliferative activity assay IC50 = 8.33 ��M 29886324
HCT116 Cytotoxicity assay IC50 = 8.41 ��M 29631788
WI38 Cytotoxicity assay IC50 = 8.42 ��M 26991938
HepG2 Cytotoxicity assay IC50 = 8.42 ��M 27162123
HepG2 Cytotoxicity assay IC50 = 8.42 ��M 23871909
HT-29 Antiproliferative activity assay IC50 = 8.44 ��M 29602674
HepG2 Cytotoxicity assay IC50 = 8.67 ��M 24675135
MCF7 Cytotoxicity assay IC50 = 8.83 ��M 20435479
MCF7 Cytotoxicity assay IC50 = 9.12 ��M 24300920
HepG2 Antiproliferative activity assay IC50 = 9.14 ��M 26560049
A375 Cytotoxicity assay IC50 = 9.17 ��M 24675135
MGC803 Antiproliferative activity assay IC50 = 9.2 ��M 29032031
SKOV3 Cytotoxicity assay IC50 = 9.25 ��M 24300920
RS4:11 Function assay GI50 = 9.3 ��M 26081023
RS4:11 Cytotoxicity assay GI50 = 9.3 ��M 23618709
MIAPaCa2 Antiproliferative activity assay IC50 = 9.32 ��M 29032031
PANC1 Growth inhibition assay IC50 = 9.32 ��M 29102175
MHCC97H Growth inhibition assay IC50 = 9.32 ��M 29102175
RS4:11 Antiproliferative activity assay GI50 = 9.4 ��M 21708468
Hep3B Cytotoxicity assay IC50 = 9.4 ��M 28865276
LoVo Growth inhibition assay IC50 = 9.47 ��M 29102175
SMMC7721 Antiproliferative activity assay IC50 = 9.96 ��M 25637123
MCF7 Cytotoxicity assay TGI = 9.97 ��M 26590508
IGROV1 Growth inhibition assay TGI = 10 ��M 28088086
ACHN Growth inhibition assay TGI = 10 ��M 28088086
TK10 Growth inhibition assay TGI = 10 ��M 28088086
786-0 Antiproliferative activity assay TGI = 10 ��M 27017549
SN12C Antiproliferative activity assay TGI = 10 ��M 27017549
Caki1 Antiproliferative activity assay LC50 = 10 ��M 27017549
TK10 Antiproliferative activity assay TGI = 10 ��M 27017549
RXF393 Antiproliferative activity assay TGI = 10 ��M 27017549
OVCAR8 Antiproliferative activity assay TGI = 10 ��M 27017549
SNB75 Antiproliferative activity assay TGI = 10 ��M 27017549
NCI-H322M Antiproliferative activity assay TGI = 10 ��M 27017549
MDA-MB-435 Antiproliferative activity assay LC50 = 10 ��M 27017549
SF539 Antiproliferative activity assay TGI = 10 ��M 27017549
SF268 Antiproliferative activity assay TGI = 10 ��M 27017549
NCI-H460 Antiproliferative activity assay TGI = 10 ��M 27017549
DU145 Antiproliferative activity assay TGI = 10 ��M 27017549
K1 Antiproliferative activity assay IC50 = 10.2 ��M 29032031
Bel7402 Cytotoxicity assay IC50 = 10.26 ��M 21504204
Bel7402 Growth inhibition assay IC50 = 10.31 ��M 29102175
OVCAR3 Cytotoxicity assay TGI = 10.32 ��M 26590508
SGC7901 Cytotoxicity assay IC50 = 10.37 ��M 20435479
SNB75 Cytotoxicity assay TGI = 10.42 ��M 26590508
A431 Antiproliferative activity assay IC50 = 10.46 ��M 29032031
SMMC7721 Antiproliferative activity assay IC50 = 10.61 ��M 29032031
GES-1 Cytotoxicity assay IC50 = 10.68 ��M 27162123
H460 Cytotoxicity assay IC50 = 10.8 ��M 24300920
BGC823 Antiproliferative activity assay IC50 = 10.91 ��M 22721924
Hep3B Cytotoxicity assay IC50 = 11.2 ��M 28342400
MCF7 Cytotoxicity assay IC50 = 11.34 ��M 27162123
MCF7 Cytotoxicity assay IC50 = 11.34 ��M 23871909
SK-MEL-2 Antiproliferative activity human IC50 = 11.35 ��M 28242553
HepG2 Cytotoxicity assay IC50 = 11.49 ��M 21504204
A375P Antiproliferative activity assay IC50 = 11.5 ��M 22014559
SGC7901 Cytotoxicity assay IC50 = 11.5 ��M 24300920
HeLa Antiproliferative activity assay IC50 = 12.01 ��M 29103873
PANC1 Cytotoxicity assay IC50 = 12.3 ��M 24300920
HepG2 Antiproliferative activity assay IC50 = 12.54 ��M 29032031
A549 Antiproliferative activity assay IC50 = 12.54 ��M 23644219
Caki1 Growth inhibition assay TGI = 12.59 ��M 28088086
OVCAR8 Growth inhibition assay TGI = 12.59 ��M 28088086
SKOV3 Antiproliferative activity assay TGI = 12.6 ��M 27017549
ACHN Antiproliferative activity assay TGI = 12.6 ��M 27017549
OVCAR3 Antiproliferative activity assay TGI = 12.6 ��M 27017549
OVCAR4 Antiproliferative activity assay TGI = 12.6 ��M 27017549
HCT15 Antiproliferative activity assay TGI = 12.6 ��M 27017549
SW620 Antiproliferative activity assay TGI = 12.6 ��M 27017549
A549/ATCC Antiproliferative activity assay TGI = 12.6 ��M 27017549
MDA-MB-468 Cytotoxicity assay TGI = 13.09 ��M 26590508
SK-MEL-28 Cytotoxicity assay TGI = 13.39 ��M 26590508
A549 Antiproliferative activity assay IC50 = 13.64 ��M 26560049
A375 Antiproliferative activity human IC50 = 13.64 ��M 28242553
A375 Antiproliferative activity assay IC50 = 13.64 ��M 25462267
K562 Antiproliferative activity assay IC50 = 13.85 ��M 23644219
Hep3B Cytotoxicity assay IC50 = 14.08 ��M 21504204
T47D Cytotoxicity assay TGI = 14.38 ��M 26590508
NCI-H226 Cytotoxicity assay TGI = 14.42 ��M 26590508
MDA-MB-231 Antiproliferative activity assay IC50 = 14.62 ��M 24440479
MDA-MB-231 Antiproliferative activity assay IC50 = 14.62 ��M 23644219
NCI-H522 Cytotoxicity assay TGI = 14.82 ��M 26590508
SK-MEL-2 Cytotoxicity assay TGI = 14.85 ��M 26590508
OS-RC2 Cytotoxicity assay IC50 = 15 ��M 29786436
HepG2 Antiproliferative activity assay IC50 = 15 ��M 29103873
fibroblast Antiproliferative activity assay IC50 = 15.1 ��M 18477505
HT-29 Cytotoxicity assay IC50 = 15.2 ��M 24675135
U87MG Cytotoxicity assay IC50 = 15.57 ��M 24826815
BT549 Antiproliferative activity assay LC50 = 15.8 ��M 27017549
GES-1 Cytotoxicity assay IC50 = 15.8 ��M 23871909
SNB19 Antiproliferative activity assay TGI = 15.85 ��M 27017549
IGROV1 Antiproliferative activity assay TGI = 15.9 ��M 27017549
HCT116 Antiproliferative activity assay LC50 = 15.9 ��M 27017549
OS-RC2 Cytotoxicity assay IC50 = 16 ��M 23454017
A375 Cytotoxicity assay IC50 = 16.24 ��M 25461318
SKOV3 Cytotoxicity assay TGI = 16.36 ��M 26590508
WM1361 Antiproliferative activity assay IC50 = 16.44 ��M 29602674
MKN28 Antiproliferative activity assay IC50 = 17 ��M 29032031
SMMC7721 Cytotoxicity assay IC50 = 17.3 ��M 21504204
UACC257 Cytotoxicity assay TGI = 17.33 ��M 26590508
EAhy926 Antiangiogenic activity assay IC50 = 18.52 ��M 29032031
SMMC7721 Cytotoxicity assay IC50 = 18.7 ��M 24300920
Ketr3 Cytotoxicity assay IC50 = 18.8 ��M 24675135
NCI-H522 Cytotoxicity assay IC50 = 19.26 ��M 25461318
A549 Cytotoxicity assay IC50 = 19.54 ��M 27162123
SH-SY5Y Cytotoxicity assay IC50 = 19.54 ��M 23871909
MGC803 Antiproliferative activity assay IC50 = 19.92 ��M 29103873
EKVX Growth inhibition assay TGI = 19.95 ��M 28088086
OVCAR5 Antiproliferative activity assay TGI = 20 ��M 27017549
UACC62 Antiproliferative activity assay LC50 = 20 ��M 27017549
UACC257 Antiproliferative activity assay LC50 = 20 ��M 27017549
MDA-MB-231 Antiproliferative activity assay LC50 = 20 ��M 27017549
U87 Cytotoxicity assay IC50 = 21.07 ��M 20435479
EJ Cytotoxicity assay IC50 = 22.9 ��M 24300920
HCT116 Antiproliferative activity assay IC50 = 23.31 ��M 29602674
HOP62 Cytotoxicity assay TGI = 23.55 ��M 26590508
MDA-MB-231 Cytotoxicity assay TGI = 23.93 ��M 26590508
PC3 Antiproliferative activity assay IC50 = 24.2 ��M 24440479
PC3 Antiproliferative activity assay IC50 = 24.2 ��M 23644219
EAhy926 Antiproliferative activity assay IC50 = 24.36 ��M 28068599
EAhy926 Anti-angiogenic activity in human IC50 = 24.36 ��M 29102175
U251 Cytotoxicity assay IC50 = 24.71 ��M 20435479
NIH/3T3 Antiproliferative activity assay IC50 = 24.75 ��M 21592628
NIH/3T3 Antiproliferative activity assay IC50 = 24.75 ��M 22647720
DU145 Cytotoxicity assay IC50 = 24.91 ��M 27162123
DU145 Cytotoxicity assay IC50 = 24.91 ��M 23871909
U251 Antiproliferative activity assay LC50 = 25.1 ��M 27017549
M14 Antiproliferative activity assay LC50 = 25.1 ��M 27017549
NCI-H522 Antiproliferative activity assay LC50 = 25.1 ��M 27017549
OVCAR4 Growth inhibition assay TGI = 25.12 ��M 28088086
SH-SY5Y Cytotoxicity assay IC50 = 27.71 ��M 27162123
A549 Cytotoxicity assay IC50 = 27.71 ��M 23871909
PLC/PRF/5 Cytotoxicity assay IC50 = 29.9 ��M 28109948
SK-MEL-5 Cytotoxicity assay TGI = 31.26 ��M 26590508
A498 Antiproliferative activity assay LC50 = 31.6 ��M 27017549
SK-MEL-28 Antiproliferative activity assay LC50 = 31.6 ��M 27017549
KM12 Antiproliferative activity assay LC50 = 31.6 ��M 27017549
COLO205 Antiproliferative activity assay LC50 = 31.6 ��M 27017549
NCI-H226 Antiproliferative activity assay LC50 = 31.6 ��M 27017549
SF295 Antiproliferative activity assay LC50 = 31.6 ��M 27017549
HOP62 Antiproliferative activity assay LC50 = 31.6 ��M 27017549
T47D Antiproliferative activity assay LC50 = 31.6 ��M 27017549
MHCC97L Cytotoxicity assay IC50 = 34.41 ��M 28109948
MDA-MB-231 Antiproliferative activity assay IC50 = 35 ��M 24315192
MDA-MB-231 Cytotoxicity assay IC50 = 36 ��M 22483592
B16-BL6 Cytotoxicity assay IC50 = 36.48 ��M 29631788
UO31 Antiproliferative activity assay LC50 = 39.8 ��M 27017549
SN12C Antiproliferative activity assay LC50 = 39.8 ��M 27017549
RXF393 Antiproliferative activity assay LC50 = 39.8 ��M 27017549
SNB75 Antiproliferative activity assay LC50 = 39.8 ��M 27017549
SF268 Antiproliferative activity assay LC50 = 39.8 ��M 27017549
NCI-H23 Antiproliferative activity assay LC50 = 39.8 ��M 27017549
HT-29 Antiproliferative activity assay LC50 = 39.8 ��M 27017549
HOP92 Antiproliferative activity assay LC50 = 39.8 ��M 27017549
NCI-H460 Antiproliferative activity assay LC50 = 39.8 ��M 27017549
SW620 Antiproliferative activity assay LC50 = 39.8 ��M 27017549
MDA-MB-468 Antiproliferative activity assay LC50 = 39.8 ��M 27017549
MALME-3M Growth inhibition assay TGI = 39.81 ��M 28088086
Click to View More Cell Line Experimental Data

Biological Activity

Description Sorafenib is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-��, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
Targets
Raf-1 [1]
(Cell-free assay)		 mVEGFR2(Flk1) [1]
(Cell-free assay)		 mVEGFR3 [1]
(Cell-free assay)		 B-Raf [1]
(Cell-free assay)		 B-Raf (V599E) [1]
(Cell-free assay)		 Click to View More Targets
6 nM 15 nM 20 nM 22 nM 38 nM
In vitro
In vitro Sorafenib inhibits both wild-type and V599E mutant B-Raf activity with IC50 of 22 nM and 38 nM, respectively. Sorafenib also potently inhibits mVEGFR2 (Flk-1), mVEGFR3, mPDGFR��, Flt3, and c-Kit with IC50 of 15 nM, 20 nM, 57 nM, 58 nM, and 68 nM, respectively. Sorafenib weakly inhibits FGFR-1 with IC50 of 580 nM. Sorafenib tosylate is not active against ERK-1, MEK-1, EGFR, HER-2, IGFR-1, c-Met, PKB, PKA, cdk1/cyclinB, PKC��, PKC��, and pim-1. Sorafenib markedly inhibits VEGFR2 phosphorylation in NIH 3T3 cells with IC50 of 30 nM, and Flt-3 phosphorylation in HEK-293 cells with IC50 of 20 nM. Sorafenib potently blocks MEK 1/2 and ERK 1/2 phosphorylation in most cell lines but not in A549 or H460 cells, while having no effect on inhibition of the PKB pathway. Sorafenib inhibits the proliferation of HAoSMC and MDA-MB-231 cells with IC50 of 0.28 ��M and 2.6 ��M, respectively. [1] In addition to inhibition of the RAF/MEK/ERK signaling pathway, Sorafenib significantly inhibits the phosphorylation of eIF4E and down-regulates Mcl-1 levels in hepatocellular carcinoma (HCC) cells in a MEK/ERK-independent manner. Sorafenib inhibits the proliferation of PLC/PRF/5 and HepG2 cells with IC50 of 6.3 ��M and 4.5 ��M, respectively, and leads to the significant induction of apoptosis. [2]
Kinase Assay Biochemical assays
Recombinant baculoviruses expressing Raf-1 (residues 305���648) and B-Raf (residues 409���765) are purified as fusion proteins. Full-length human MEK-1 is generated by PCR and purified as a fusion protein from Escherichia coli lysates. Sorafenib tosylate is added to a mixture of Raf-1 (80 ng), or B-Raf (80 ng) with MEK-1 (1 ��g) in assay buffer [20 mM Tris (pH 8.2), 100 mM NaCl, 5 mM MgCl2, and 0.15% ��-mercaptoethanol] at a final concentration of 1% DMSO. The Raf kinase assay (final volume of 50 ��L) is initiated by adding 25 ��L of 10 ��M ��[33P]ATP (400 Ci/mol) and incubated at 32 ��C for 25 minutes. Phosphorylated MEK-1 is harvested by filtration onto a phosphocellulose mat, and 1% phosphoric acid is used to wash away unbound radioactivity. After drying by microwave heating, a ��-plate counter is used to quantify filter-bound radioactivity. Human VEGFR2 (KDR) kinase domain is expressed and purified from Sf9 lysates. Time-resolved fluorescence energy transfer assays for VEGFR2 are performed in 96-well opaque plates in the time-resolved fluorescence energy transfer format. Final reaction conditions are as follows: 1 to 10 ��M ATP, 25 nM poly GT-biotin, 2 nM Europium-labeled phospho (p)-Tyr antibody (PY20), 10 nM APC, 1 to 7 nM cytoplasmic kinase domain in final concentrations of 1% DMSO, 50 mM HEPES (pH 7.5), 10 mM MgCl2, 0.1 mM EDTA, 0.015% Brij-35, 0.1 mg/mL BSA, and 0.1% ��-mercaptoethanol. Reaction volumes are 100 ��L and are initiated by addition of enzyme. Plates are read at both 615 and 665 nM on a Perkin-Elmer VictorV Multilabel counter at ~1.5 to 2.0 hours after reaction initiation. Signal is calculated as a ratio: (665 nm/615 nM) �� 10,000 for each well. For IC50 generation, Sorafenib tosylate is added before the enzyme initiation. A 50-fold stock plate is made with Sorafenib tosylate serially diluted 1:3 in a 50% DMSO/50% distilled water solution. Final Sorafenib tosylate concentrations range from 10 ��M to 4.56 nM in 1% DMSO.
Cell Research Cell lines MDA-MB-231, and HAoSMC
Concentrations Dissolved in DMSO, final concentrations ~10 ��M
Incubation Time 72 hours
Method

Cells are exposed to increasing concentrations of Sorafenib tosylate for 72 hours. Cell number is quantitated using the Cell TiterGlo ATP Luminescent assay kit. This assay measures the number of viable cells per well by measurement of luminescent signal based on amount of cellular ATP.
Experimental Result Images Methods Biomarkers Images PMID
Western blot LC3-I / LC-3II / ATG5 p-STAT3 / STAT3 / Mcl-1 ��-catenin / Survivin / Mcl-1 / PTMA pERK / ERK p-PKM2(y105) / PMK2 / Caspase-9 RET(pY1016) / VEGFR2(pY1214) / MEK1(pT292) / ERK(pY204) Cyclin D1 23392173
Growth inhibition assay Cell viability 26039995
Immunofluorescence p65 cytochrome c 22286758
ELISA TGF-beta / CD206 Caspase-9 / Caspase-3 26158762
In Vivo
In vivo Oral administration of Sorafenib (~60 mg/kg) demonstrates broad spectrum, dose-dependent anti-tumor activity against a variety of human tumor xenograft models including MDA-MB-231, Colo-205, HT-29, DLD-1, NCI-H460, and A549, with no evidence of toxicity. In association with the anti-tumor efficacy, Sorafenib treatment potently inhibits MEK 1/2 phosphorylation and pERK 1/2 levels in HT-29 and MDA-MB-231 xenografts but not in Colo-205 xenografts, and significantly suppresses tumor microvessel area (MVA) and microvessel density (MVD) in MDA MB-231, HT-29 and Colo-205 tumor xenografts. [1] Sorafenib treatment produces dose-dependent growth inhibition of PLC/PRF/5 tumor xenografts in SCID mice with TGIs of 49% and 78% at 10 mg/kg and 30 mg/kg, respectively, consistent with the inhibition of ERK and eIF4E phosphorylation, reduction of the microvessel area, and induction of tumor cell apoptosis. [2] Sorafenib sensitizes bax-/- cells to TRAIL in a dose-dependent manner, through a mechanism involving down-regulating NF-��B mediated Mcl-1 and cIAP2 expression. Combining Sorafenib (30-60 mg/kg) with TRAIL (5 mg/kg) show dramatic efficacy in TRAIL-resistant HCT116 bax-/- and HT29 tumor xenografts. [3]
Animal Research Animal Models Female NCr-nu/nu mice implanted s.c. with MDA-MB-231, Colo-205, HT-29, H460, or A549 cells
Dosages ~60 mg/kg
Administration Orally once daily
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05068752 Recruiting
Pancreas Cancer
HonorHealth Research Institute|Bayer|Genentech Inc.
 October 28 2021 Phase 2
NCT04763408 Active not recruiting
Carcinoma Hepatocellular
Eisai Inc.
 April 9 2021 --

Chemical Information & Solubility

Molecular Weight 464.82 Formula

C21H16ClF3N4O3
CAS No. 284461-73-0 SDF Download Sorafenib SDF
Smiles CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 92 mg/mL ( (197.92 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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Tech Support

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