Home Apoptosis Antioxidant chemical Sesamol For research use only.

Sesamol

Synonyms: 1,3-Benzodioxol-5-ol, 3,4-Methylenedioxyphenol

Sesamol (1,3-Benzodioxol-5-ol, 3,4-Methylenedioxyphenol), a natural organic compound, is regarded as a major antioxidant component in the oil with chemoprevention, antimutagenic, and antihepatotoxic activities. It induces apoptosis of cancer and cardiovascular cells.

Sesamol Chemical Structure

Sesamol Chemical Structure

CAS No. 533-31-3

Purity & Quality Control

Batch: S362601 DMSO]27 mg/mL]false]Water]27 mg/mL]false]Ethanol]27 mg/mL]false Purity: 99.96%
99.96

Sesamol Related Products

Biological Activity

Description Sesamol (1,3-Benzodioxol-5-ol, 3,4-Methylenedioxyphenol), a natural organic compound, is regarded as a major antioxidant component in the oil with chemoprevention, antimutagenic, and antihepatotoxic activities. It induces apoptosis of cancer and cardiovascular cells.
In vitro
In vitro

Sesamol treatment suppresses colony formation, elicits S phase arrest during cell cycle progression, and induces both intrinsic and extrinsic apoptotic pathway in vitro with a dose-dependent manner. Furthermore, sesamol treatment elicits mitochondrial dysfunction by inducing a loss of mitochondrial membrane potential. Impaired mitochondria and accumulated H2O2 production results in disturbance of redox-sensitive signaling including Akt and MAPKs pathways. Mitochondrial biogenesis is inhibited as suggested by the decline in expression of mitochondrial complex I subunit ND1, and the upstream AMPK/PGC1α signals. Importantly, sesamol inhibits mitophagy and autophagy through impeding the PI3K Class III/Belin-1 pathway. Autophagy stimulator rapamycin reverses sesamol-induced apoptosis and mitochondrial respiration disorders[1]. Sesamol increases the activity of caspase 8, 9, and 3/7, indicating that apoptotic cell death occurred through both extrinsic and intrinsic pathways. Sesamol causes the loss of mitochondrial transmembrane potential signifying intrinsic apoptosis induction in human lung adenocarcinoma (SK-LU-1) cells[2].
Cell Research Cell lines HepG2 cells, BRL-3A cells
Concentrations 0, 0.01, 0.05, 0.1, 0.2, 0.5 or 1 mM
Incubation Time 24 h
Method

The cytotoxicity of sesamol on HepG2 cells and BRL-3A cells is examined by using MTT assay. Briefly, cells in exponential growth are seeded into 96-well plates at a density of 1 × 105 cells/mL. The cells are then treated with sesamol at various doses (0, 0.01, 0.05, 0.1, 0.2, 0.5 or 1 mM). After 24 h, the supernatant is discarded and 100 μL FBS free medium is added. 100 μL of MTT is added in each well, and cells are further incubated for 4 h in the dark. After incubation, the medium is discarded, 100 μL of DMSO is added, and the optical density of each well is measured at 570 nm.
In Vivo
In vivo

Sesamol has potent anti-hepatoma activity in a xenograft nude mice model[1].
Animal Research Animal Models Balb/c nu/nu mice
Dosages 100 mg/kg or 200 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 138.12 Formula

C7H6O3
CAS No. 533-31-3 SDF Download Sesamol SDF
Smiles C1OC2=C(O1)C=C(C=C2)O
Storage (From the date of receipt) 3 years -20°C powder (seal)

In vitro
Batch:

DMSO : 27 mg/mL ( (195.48 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 27 mg/mL

Ethanol : 27 mg/mL


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In vivo
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