Home Neuronal Signaling AChR antagonist Scopolamine For research use only.

Scopolamine

Synonyms: Skopolamin

Scopolamine (Skopolamin) is a tropane alkaloid derived from plants of the nightshade family, specifically Hyoscyamus niger and Atropa belladonna, with anticholinergic, antiemetic and antivertigo properties.

Scopolamine Chemical Structure

Scopolamine Chemical Structure

CAS No. 51-34-3

Purity & Quality Control

Scopolamine Related Products

Signaling Pathway

AChR Signaling Pathways

AChR Signaling Pathway

Biological Activity

Description Scopolamine (Skopolamin) is a tropane alkaloid derived from plants of the nightshade family, specifically Hyoscyamus niger and Atropa belladonna, with anticholinergic, antiemetic and antivertigo properties.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05759481 Recruiting
Post-operative Nausea and Vomiting
Milton S. Hershey Medical Center
 February 1 2024 Phase 2
NCT04999449 Recruiting
Scopolamine|Motion Sickness
Dartmouth-Hitchcock Medical Center
 January 24 2022 Phase 1
NCT04314713 Terminated
Scopolamine Causing Adverse Effects in Therapeutic Use
Battelle Memorial Institute
 June 2 2020 Phase 1
NCT03874130 Unknown status
Major Depressive Disorder (MDD)
Repurposed Therapeutics Inc.
 August 1 2018 Phase 1
NCT03294109 Completed
Pain Postoperative|Analgesics Opioid|Analgesics Non-Narcotic|Physiological Effects of Drugs|Peripheral Nervous System Agents|Patient Satisfaction|Return to Work|Activity Sexual
University of California Los Angeles
 January 1 2018 Phase 4

Chemical Information & Solubility

Molecular Weight 303.35 Formula

C17H21NO4
CAS No. 51-34-3 SDF --
Density 1.31 g/mL
Storage (From the date of receipt) 2 years -20°C liquid

In vitro
Batch:

DMSO : 61 mg/mL ( (201.08 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 61 mg/mL

Ethanol : 61 mg/mL


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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