Home GPCR & G Protein Adenosine Receptor antagonist SCH-442416 For research use only.

SCH-442416

SCH-442416 is a selective antagonist of adenosine A2A receptor that binds to human and rat adenosine A2A receptors with Ki of 0.048 nM and 0.5 nM, respectively.

SCH-442416 Chemical Structure

SCH-442416 Chemical Structure

CAS No. 316173-57-6

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SCH-442416 Related Products

Biological Activity

Description SCH-442416 is a selective antagonist of adenosine A2A receptor that binds to human and rat adenosine A2A receptors with Ki of 0.048 nM and 0.5 nM, respectively.
Targets
Human A2A receptor [1]
(Cell-free assay)		 Rat A2A receptor [1]
(Cell-free assay)
0.048 nM(Ki) 0.5 nM(Ki)
In vitro
In vitro

SCH-442416 is a selective antagonist of adenosine A2A receptor that binds to human and rat adenosine A2A receptors with Ki of 0.048 nM and 0.5 nM, respectively.
In Vivo
In vivo

SCH-442416 (0.017 mg/kg; i.p.) completely abrogates the CGS-21680-induced decrease in skeletal muscle injury.
Animal Research Animal Models C57BL/6 mice
Dosages 0.017 mg/ kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00531193 Completed
Healthy
Biogen
 September 2007 Phase 1

Chemical Information & Solubility

Molecular Weight 389.41 Formula

C20H19N7O2
CAS No. 316173-57-6 SDF --
Smiles COC1=CC=C(CCC[N]2N=CC3=C2N=C(N)[N]4N=C(N=C34)C5=CC=CO5)C=C1
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 78 mg/mL ( (200.3 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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