Sarilumab (anti-IL-6Rα)

Synonyms: SAR153191, REGN88

Catalog No.A2011 Purity:98.05%

Sarilumab (anti-IL-6Rα) is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity, MW: 144.13 KD.

Sarilumab (anti-IL-6Rα) Chemical Structure

Click to purchase the isotype control of Sarilumab (anti-IL-6Rα)

Selleck's Sarilumab (anti-IL-6Rα) has been cited by 4 publications

Purity & Quality Control

Batch: A201101 Purity: 98.05% Protein concentration: 5.0 mg/ml Endotoxin Level: ≤1 EU/mg

98.05

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description

Sarilumab (anti-IL-6Rα) is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity, MW: 144.13 KD.

Features

Human IgG1

Targets

IL-6R (human) ^[1]	IL-6R (monkey) ^[1]
61.9 pM(Kd)	71.9 pM(Kd)

In Vitro
In vitro	Sarilumab can reverse IL-6 enhanced colony formation in HCC cells under sorafenib or regorafenib treatment.^[1]
Cell Research:	Cells were treated with drugs for 36 h. The soluble form of IL-6Rα in cell culture supernatants was measured with a human IL-6Rα ELISA kit according to the manufacturer’s instructions. Plates were measured on a microplate reader at a wavelength of 450 nm.

In Vitro

In vitro

Sarilumab can reverse IL-6 enhanced colony formation in HCC cells under sorafenib or regorafenib treatment.^[1]

Cell Research:

Cells were treated with drugs for 36 h. The soluble form of IL-6Rα in cell culture supernatants was measured with a human IL-6Rα ELISA kit according to the manufacturer’s instructions. Plates were measured on a microplate reader at a wavelength of 450 nm.

In Vivo
In vivo	Sarilumab has been shown in preclinical studies to inhibit IL-6 signalling in a dose-dependent manner^[2].

References
[1] Dai Z, et al. Cancer Lett. 2022 Jan 1;524:161-171. [2] Huizinga TW, et al. Ann Rheum Dis. 2014, 73(9):1626-34.

References

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1189541-98-7
Isotype	Human IgG1
Source	CHO cells
Formulation	PBS buffer, pH 7.2
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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Frequently Asked Questions

Question 1:
How to store the antibody?

Answer:
Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.