Home DNA Damage/DNA Repair PARP inhibitor Rucaparib Camsylate For research use only.

Rucaparib Camsylate

Synonyms: Rubraca, AG014699 Camsylate, PF01367338 Camsylate

Rucaparib (Rubraca, AG014699, PF01367338) Camsylate is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains.

Rucaparib Camsylate Chemical Structure

Rucaparib Camsylate Chemical Structure

CAS No. 1859053-21-6

Purity & Quality Control

Batch: S519501 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.96%
99.96

Rucaparib Camsylate Related Products

Signaling Pathway

PARP Signaling Pathways

PARP Signaling Pathway

Biological Activity

Description Rucaparib (Rubraca, AG014699, PF01367338) Camsylate is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains.
Targets
PARP1 [1]
(Cell-free assay)
1.4 nM(Ki)
In vitro
In vitro

Deletion of ATM does not impact sensitivity to PARP inhibition by rucaparib.[2]
Cell Research Cell lines Human prostate cancer lines DU145, ATM-deficient isogenic DU145 cells
Concentrations 0-5 µM
Incubation Time 3-4 days
Method

Cells were seeded into 24-well plates (2,500–4000 cells/well) and treated with increasing concentrations of drug the following day. Cell viability was assessed after 72–96 hours by adding CellTiter-Glo reagent and measuring luminescence using a plate reader. For clonogenic survival assays, cells were seeded in 6-well plates (500–4000 cells/well) in triplicate. Cells were treated with drug 16 to 18 hours after plating and were allowed to grow for 14 days.

(Data sourced from selleck products)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01009190 Completed
Advanced Solid Tumors
pharmaand GmbH
 February 2010 Phase 1

Chemical Information & Solubility

Molecular Weight 555.66 Formula

C29H34FN3O5S
CAS No. 1859053-21-6 SDF --
Smiles CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=C3C(=CC(=C4)F)[NH]2.CC5(C)C6CCC5(C[S](O)(=O)=O)C(=O)C6
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (179.96 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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