Home Transmembrane Transporters GABA Receptor modulator RO5186582 For research use only.

RO5186582

Synonyms: Basmisanil, RG1662

RO5186582 (Basmisanil, RG1662) is a highly selective GABAAα5 negative allosteric modulator.

RO5186582 Chemical Structure

RO5186582 Chemical Structure

CAS No. 1159600-41-5

Purity & Quality Control

Batch: E096001 DMSO]89 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.94%
99.94

RO5186582 Related Products

Signaling Pathway

GABA Receptor Signaling Pathways

GABA Receptor Signaling Pathway

Biological Activity

Description RO5186582 (Basmisanil, RG1662) is a highly selective GABAAα5 negative allosteric modulator.
Targets
GABAAα5 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05307679 Completed
Dup15q Syndrome
Hoffmann-La Roche
 December 16 2022 Phase 2
NCT02928393 Terminated
Stroke
Hoffmann-La Roche
 February 20 2017 Phase 2
NCT02953639 Completed
Schizophrenia
Hoffmann-La Roche
 November 30 2016 Phase 2
NCT02484703 Terminated
Down Syndrome
Hoffmann-La Roche
 October 28 2015 Phase 2
NCT02534207 Completed
Healthy Volunteer
Hoffmann-La Roche
 August 2015 Phase 1
NCT02470832 Completed
Healthy Patient Study
Hoffmann-La Roche
 May 2015 Phase 1

Chemical Information & Solubility

Molecular Weight 445.47 Formula

C21H20FN3O5S
CAS No. 1159600-41-5 SDF --
Smiles CC1=C(COC2=CC=C(C=N2)C(=O)N3CC[S;v6](=O)(=O)CC3)C(=NO1)C4=CC=C(F)C=C4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 89 mg/mL ( (199.78 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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