Home Cytoskeletal Signaling Integrin inhibitor - Apoptosis related activator - Caspase activator RGD peptide (GRGDNP) For research use only.

RGD peptide (GRGDNP)

RGD peptide (GRGDNP) is an inhibitor of binding of integrins to the extracellular matrixs. RGD peptide (GRGDNP) induces apoptosis presumably through direct activation of caspase-3.

RGD peptide (GRGDNP) Chemical Structure

RGD peptide (GRGDNP) Chemical Structure

CAS No. 114681-65-1

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RGD peptide (GRGDNP) Related Products

Signaling Pathway

Integrin Signaling Pathways

Integrin Signaling Pathway

Biological Activity

Description RGD peptide (GRGDNP) is an inhibitor of binding of integrins to the extracellular matrixs. RGD peptide (GRGDNP) induces apoptosis presumably through direct activation of caspase-3.
Targets
integrin [1] caspase-3 [2]
In vitro
In vitro

RGD-peptide interfers with cell proliferation by affecting cell protrusion and stress fibers.[3]
Cell Research Cell lines MC3T3-E1: ATCC CRL-2594 cell line
Concentrations 1,000 µM
Incubation Time 24 h
Method

For inhibition of cell attachment, MC3T3-E1 cells were incubated at 37°C for 24 hours in the presence of 5 mM EDTA, 1,000 µM RGD, 10 µg/mL MAB1998, 0.2 µL IgG, and 10 µg/mL heparin. Next, the cells (500 µL, 5,000 cells/well) were added to the wells and incubated for 24 hours. To measure cell proliferation on the specimens, a metabolic activity cell counting kit assay was used in this experiment.

(Data sourced from selleck products)

Chemical Information & Solubility

Molecular Weight 614.61 Formula

C23H38N10O10
CAS No. 114681-65-1 SDF --
Smiles NCC(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)NC(CC(O)=O)C(=O)NC(CC(N)=O)C(=O)N1CCCC1C(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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