Home MAPK Raf inhibitor PF-07799933 For research use only.

PF-07799933

Synonyms: Claturafenib, ARRY-440

PF-07799933 (Claturafenib, ARRY-440) is a brain-penetrant, selective, pan-mutant inhibitor of BRAF. It exhibits broad inhibition of pERK levels in HT29 cells with an IC50 value of 1.6 nM. PF-07799933 treatment displays antitumor activity against BRAFV600- and non-V600-mutant cancers preclinically and in treatment-refractory patients.

PF-07799933 Chemical Structure

PF-07799933 Chemical Structure

CAS No. 2754408-94-9

Purity & Quality Control

Batch: E468101 DMSO]98 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.20%
99.20

PF-07799933 Related Products

Signaling Pathway

Raf Signaling Pathways

Raf Signaling Pathway

Biological Activity

Description PF-07799933 (Claturafenib, ARRY-440) is a brain-penetrant, selective, pan-mutant inhibitor of BRAF. It exhibits broad inhibition of pERK levels in HT29 cells with an IC50 value of 1.6 nM. PF-07799933 treatment displays antitumor activity against BRAFV600- and non-V600-mutant cancers preclinically and in treatment-refractory patients.

Chemical Information & Solubility

Molecular Weight 490.31 Formula

C18H15Cl2F2N5O3S
CAS No. 2754408-94-9 SDF Download PF-07799933 SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 98 mg/mL ( (199.87 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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