Home GPCR & G Protein GPR agonist - ERK activator Pamoic acid disodium For research use only.

Pamoic acid disodium

Pamoic acid disodium, a potent GPR35 agonist with an EC50 value of 79 nM, induces GPR35a internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively, also potently recruits β-arrestin2 to GPR35 showing an antinociceptive effect.

Pamoic acid disodium Chemical Structure

Pamoic acid disodium Chemical Structure

CAS No. 6640-22-8

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Pamoic acid disodium Related Products

Biological Activity

Description Pamoic acid disodium, a potent GPR35 agonist with an EC50 value of 79 nM, induces GPR35a internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively, also potently recruits β-arrestin2 to GPR35 showing an antinociceptive effect.
Targets
GPR35a [1]
(in internalization assay)		 ERK1/2 [1]
(in western blot analysis for determination of ERK activity)		 GPR35 [1]
(in β-arrestin assay)
22 nM(EC50) 65 nM(EC50) 79 nM(EC50)

Chemical Information & Solubility

Molecular Weight 432.33 Formula

C23H16O6.2Na
CAS No. 6640-22-8 SDF --
Smiles [Na+].[Na+].OC1=C(C=C2C=CC=CC2=C1CC3=C4C=CC=CC4=CC(=C3O)C([O-])=O)C([O-])=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 86 mg/mL

DMSO : 29 mg/mL ( (67.07 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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