Home GPCR & G Protein GPR agonist 3-chloro-5-hydroxybenzoic Acid For research use only.

3-chloro-5-hydroxybenzoic Acid

3-chloro-5-hydroxybenzoic Acid is a selective agonist of the lactate receptor GPR81.

3-chloro-5-hydroxybenzoic Acid Chemical Structure

3-chloro-5-hydroxybenzoic Acid Chemical Structure

CAS No. 53984-36-4

Purity & Quality Control

Batch: S540001 DMSO]34 mg/mL]false]Water]Insoluble]false]]]false Purity: 99.3%
99.3

3-chloro-5-hydroxybenzoic Acid Related Products

Biological Activity

Description 3-chloro-5-hydroxybenzoic Acid is a selective agonist of the lactate receptor GPR81.
In vitro
In vitro

3-Chloro-5-hydroxybenzoic acid shows potency against human (EC50=16 μM), monkey (EC50=17 μM), dog (EC50=67 μM), rat (EC50=7 μM), mouse (EC50=22 μM), and hamster GPR81 (EC50=27 μM).[1]
In Vivo
In vivo

3-Chloro-5-hydroxybenzoic acid (30 mg/kg, 100 mg/kg, 300 mg/kg) shows significant reductions in free fatty acids, resulting in a minimum efficacious dose of 30 mg/kg.[1]

Chemical Information & Solubility

Molecular Weight 172.57 Formula

C7H5ClO3
CAS No. 53984-36-4 SDF --
Smiles C1=C(C=C(C=C1O)Cl)C(=O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 34 mg/mL ( (197.02 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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