Home Cell Cycle ROCK inhibitor Netarsudil (AR-13324) 2HCl For research use only.

Netarsudil (AR-13324) 2HCl

Netarsudil (AR-13324) is a ROCK inhibitor with Ki value of 0.2-10.3 nM. It is currently in clinical trials for the treatment of glaucoma and ocular hypertension.

Netarsudil (AR-13324) 2HCl Chemical Structure

Netarsudil (AR-13324) 2HCl Chemical Structure

CAS No. 1253952-02-1

Purity & Quality Control

Netarsudil (AR-13324) 2HCl Related Products

Signaling Pathway

ROCK Signaling Pathways

ROCK Signaling Pathway

Biological Activity

Description Netarsudil (AR-13324) is a ROCK inhibitor with Ki value of 0.2-10.3 nM. It is currently in clinical trials for the treatment of glaucoma and ocular hypertension.
Targets
norepinephrine transporter (NET) [3] ROCK [1]
2 nM(Ki)
In Vivo
In vivo

Netarsudil primarily targets cells in the conventional outflow tract, efficiently decreasing IOP in both human and non-human primate eyes. In addition, netarsudil has been shown to increase outflow facility in non-human primate eyes and to decrease episcleral venous pressure in rabbit eyes[2].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06033703 Not yet recruiting
Rhegmatogenous Retinal Detachment|Proliferative Vitreoretinopathy
Massachusetts Eye and Ear Infirmary
 February 2024 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 526.45 Formula

C28H27N3O3.2HCl
CAS No. 1253952-02-1 SDF Download Netarsudil (AR-13324) 2HCl SDF
Smiles CC1=CC(=C(C=C1)C(=O)OCC2=CC=C(C=C2)C(CN)C(=O)NC3=CC4=C(C=C3)C=NC=C4)C.Cl.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (189.95 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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