Home Transmembrane Transporters MCT inhibitor MSC-4381 For research use only.

MSC-4381

Synonyms: MCT4-IN-1

MSC-4381 (MCT4-IN-1) is an orally active, selective inhibitor of monocarboxylate transporter 4 (MCT4) with an IC50 of 77 nM and a Ki of 11 nM. It has the potential to inhibit lactate efflux and promote intracellular lactate accumulation in MCT4-expressing cell lines.

MSC-4381 Chemical Structure

MSC-4381 Chemical Structure

CAS No. 2445185-57-7

Purity & Quality Control

Batch: E175101 DMSO]33 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.41%
99.41

MSC-4381 Related Products

Biological Activity

Description MSC-4381 (MCT4-IN-1) is an orally active, selective inhibitor of monocarboxylate transporter 4 (MCT4) with an IC50 of 77 nM and a Ki of 11 nM. It has the potential to inhibit lactate efflux and promote intracellular lactate accumulation in MCT4-expressing cell lines.

Chemical Information & Solubility

Molecular Weight 537.97 Formula

C26H20ClN3O6S
CAS No. 2445185-57-7 SDF Download MSC-4381 SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 33 mg/mL ( (61.34 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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