Home Transmembrane Transporters MCT inhibitor BAY-8002 For research use only.

BAY-8002

BAY-8002 is a novel MCT1 inhibitor and potently suppress bidirectional lactate transport. BAY-8002 significantly increases intratumor lactate levels and transiently modulates pyruvate levels.

BAY-8002 Chemical Structure

BAY-8002 Chemical Structure

CAS No. 724440-27-1

Purity & Quality Control

BAY-8002 Related Products

Biological Activity

Description BAY-8002 is a novel MCT1 inhibitor and potently suppress bidirectional lactate transport. BAY-8002 significantly increases intratumor lactate levels and transiently modulates pyruvate levels.
Targets
MCT [1]
In vitro
In vitro

BAY-8002 inhibits cellular SNARF-5 fluorescence change with an IC50 of 85 (±6) nmol/L in MCT1-expressing DLD-1 cells and displays excellent selectivity against MCT4 (IC50 > 50 μmol/L in EVSA-T cells). BAY-8002 is a dual inhibitor of MCT1 and MCT2[1].
Experimental Result Images Methods Biomarkers Images PMID
Growth inhibition assay Cell viability 30115664

Chemical Information & Solubility

Molecular Weight 415.85 Formula

C20H14ClNO5S
CAS No. 724440-27-1 SDF --
Smiles C1=CC=C(C=C1)S(=O)(=O)C2=CC(=C(C=C2)Cl)C(=O)NC3=CC=CC=C3C(=O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 83 mg/mL ( (199.59 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 21 mg/mL

Water : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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