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Technical Data
| Formula | C20H14ClNO5S |
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| Molecular Weight | 415.85 | CAS No. | 724440-27-1 | |
| Solubility (25°C)* | In vitro | DMSO | 83 mg/mL (199.59 mM) | |
| Ethanol | 28 mg/mL (67.33 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | BAY-8002 is a novel MCT1 inhibitor and potently suppress bidirectional lactate transport. BAY-8002 significantly increases intratumor lactate levels and transiently modulates pyruvate levels. | |
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| In vitro | BAY-8002 inhibits cellular SNARF-5 fluorescence change with an IC50 of 85 (±6) nmol/L in MCT1-expressing DLD-1 cells and displays excellent selectivity against MCT4 (IC50 > 50 μmol/L in EVSA-T cells). BAY-8002 is a dual inhibitor of MCT1 and MCT2[1]. |
Protocol (from reference)
Selleck's BAY-8002 has been cited by 5 publications
| Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation [ Cell Metab, 2024, S1550-4131(24)00415-7] | PubMed: 39577415 |
| Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors [ Cell Chem Biol, 2023, 30(8):953-964.e9] | PubMed: 37516113 |
| Distinct metabolic states guide maturation of inflammatory and tolerogenic dendritic cells [ Nat Commun, 2022, 13(1):5184] | PubMed: 36056019 |
| PXR Modulates the Prostate Cancer Cell Response to Afatinib by Regulating the Expression of the Monocarboxylate Transporter SLC16A1 [ Cancers (Basel), 2021, 13(14)3635] | PubMed: 34298852 |
| Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma. [ Cancer Discov, 2017, 7(9):1018-1029] | PubMed: 28619981 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.