Home GPCR & G Protein GPR agonist - Apoptosis related modulator - Autophagy modulator Monomethyl Fumarate For research use only.

Monomethyl Fumarate

Synonyms: MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate

Monomethyl Fumarate (MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate), the active metabolite of the psoriasis drug Fumaderm, is a potent GPR109A agonist. Monomethyl Fumarate prevents major dysfunctions associated with neurodegenerative diseases: oxidative stress, mitochondrial dysfunction, apoptosis and autophagy.

Monomethyl Fumarate Chemical Structure

Monomethyl Fumarate Chemical Structure

CAS No. 2756-87-8

Purity & Quality Control

Monomethyl Fumarate Related Products

Biological Activity

Description Monomethyl Fumarate (MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate), the active metabolite of the psoriasis drug Fumaderm, is a potent GPR109A agonist. Monomethyl Fumarate prevents major dysfunctions associated with neurodegenerative diseases: oxidative stress, mitochondrial dysfunction, apoptosis and autophagy.
Targets
GPR109A [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05858970 Not yet recruiting
Optical Biopsy|Colonic Dysplasia|Diagnostic Accuracy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
 April 1 2024 --
NCT06066957 Recruiting
Cytomegalovirus Infections|Transplant-Related Disorder
University of Pennsylvania|Merck Sharp & Dohme LLC
 April 4 2024 Phase 2
NCT05538208 Recruiting
Lupus Nephritis
Children''s Hospital Medical Center Cincinnati|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)|Genentech Inc.
 January 2024 Phase 2
NCT04776473 Recruiting
Intra-articular Fracture of the Mandibular Condyle
Assistance Publique - Hôpitaux de Paris
 May 3 2023 Not Applicable

Chemical Information & Solubility

Molecular Weight 130.10 Formula

C5H6O4
CAS No. 2756-87-8 SDF --
Smiles COC(=O)\C=C\C(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 26 mg/mL ( (199.84 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 26 mg/mL

Water : 20 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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