Home JAK/STAT Pim inhibitor - FLT3 inhibitor MEN1703(SEL24,SEL24-B489) For research use only.

MEN1703(SEL24,SEL24-B489)

Synonyms: SEL24, Pim/flt3 kinase inhibitor SEL24

MEN1703(SEL24-B489,SEL24, Pim/flt3 kinase inhibitor SEL24) is a potent, type I, orally active, dual inhibitor of PIM and FLT3-ITD, that exhibits Kd values of 2 nM for PIM1, 2 nM for PIM2 and 3 nM for PIM3, respectively. MEN1703 exhibits its broad therapeutic potential in treatment of acute myeloid leukemia.

MEN1703(SEL24,SEL24-B489) Chemical Structure

MEN1703(SEL24,SEL24-B489) Chemical Structure

CAS No. 1616359-00-2

Purity & Quality Control

Batch: E459801 DMSO]89 mg/mL]false]Ethanol]5 mg/mL]false]Water]Insoluble]false Purity: 99.44%
99.44

MEN1703(SEL24,SEL24-B489) Related Products

Signaling Pathway

Pim Signaling Pathways

Pim Signaling Pathway

Biological Activity

Description MEN1703(SEL24-B489,SEL24, Pim/flt3 kinase inhibitor SEL24) is a potent, type I, orally active, dual inhibitor of PIM and FLT3-ITD, that exhibits Kd values of 2 nM for PIM1, 2 nM for PIM2 and 3 nM for PIM3, respectively. MEN1703 exhibits its broad therapeutic potential in treatment of acute myeloid leukemia.

Chemical Information & Solubility

Molecular Weight 446.14 Formula

C15H18Br2N4O2
CAS No. 1616359-00-2 SDF Download MEN1703(SEL24,SEL24-B489) SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 89 mg/mL ( (199.48 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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