Home JAK/STAT Pim inhibitor TP-3654 For research use only.

TP-3654

TP-3654 is the second-generation PIM inhibitor with Ki values of 5 nM, 239 nM, and 42 nM for PIM-1, PIM-2 and PIM-3, respectively.

TP-3654 Chemical Structure

TP-3654 Chemical Structure

CAS No. 1361951-15-6

Purity & Quality Control

Batch: S677401 DMSO]84 mg/mL]false]Ethanol]6 mg/mL]false]Water]Insoluble]false Purity: 99.94%
99.94

TP-3654 Related Products

Signaling Pathway

Pim Signaling Pathways

Pim Signaling Pathway

Biological Activity

Description TP-3654 is the second-generation PIM inhibitor with Ki values of 5 nM, 239 nM, and 42 nM for PIM-1, PIM-2 and PIM-3, respectively.
Targets
Pim1 [1]
(Cell-free assay)		 Pim3 [1]
(Cell-free assay)		 Pim2 [1]
(Cell-free assay)
5 nM(Ki) 42 nM(Ki) 239 nM(Ki)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06389955 Completed
Healthy
Sumitomo Pharma America Inc.
 May 22 2023 Phase 1
NCT04176198 Recruiting
Myelofibrosis
Sumitomo Pharma America Inc.
 December 16 2019 Phase 1|Phase 2
NCT03715504 Completed
Advanced Solid Tumors
Sumitomo Pharma America Inc.
 April 16 2019 Phase 1

Chemical Information & Solubility

Molecular Weight 418.46 Formula

C22H25F3N4O
CAS No. 1361951-15-6 SDF --
Smiles CC(C)(C1CCC(CC1)NC2=NN3C(=NC=C3C4=CC(=CC=C4)C(F)(F)F)C=C2)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 84 mg/mL ( (200.73 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 6 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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