Home Metabolism FXR antagonist - Histamine Receptor antagonist Mebhydroline For research use only.

Mebhydroline

Mebhydroline acts as a selective antagonist of farnesoid X receptor (FXR). Mebhydrolin improves blood glucose balance in in vivo mice models by inhibiting hepatic gluconeogenesis through the FXR/miR-22-3p/PI3K/AKT/FoxO1 pathway and enhancing glycogen synthesis. It also acts as a specific antagonist of histamine H1 receptor. It has potential for its use in the treatment of Type 2 diabetes mellitus (T2DM).

Mebhydroline Chemical Structure

Mebhydroline Chemical Structure

CAS No. 524-81-2

Purity & Quality Control

Batch: E487301 DMSO]55 mg/mL]false]Ethanol]18 mg/mL]false]Water]Insoluble]false Purity: 99.83%
99.83

Mebhydroline Related Products

Biological Activity

Description Mebhydroline acts as a selective antagonist of farnesoid X receptor (FXR). Mebhydrolin improves blood glucose balance in in vivo mice models by inhibiting hepatic gluconeogenesis through the FXR/miR-22-3p/PI3K/AKT/FoxO1 pathway and enhancing glycogen synthesis. It also acts as a specific antagonist of histamine H1 receptor. It has potential for its use in the treatment of Type 2 diabetes mellitus (T2DM).

Chemical Information & Solubility

Molecular Weight 276.38 Formula

C19H20N2
CAS No. 524-81-2 SDF Download Mebhydroline SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 55 mg/mL ( (199.0 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 18 mg/mL

Water : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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