Home Metabolism FXR antagonist Guggulsterone E&Z For research use only.

Guggulsterone E&Z

Guggulsterone is one of the active constituent of Commiphora mukul. It occurs in two isomeric forms, namely Z-GS and E-GS. Guggulsterone act as antagonist ligands for the bile acid receptor, farnesoid X receptor, and as active ingredients responsible for the hypolipidemic activity.

Guggulsterone E&Z Chemical Structure

Guggulsterone E&Z Chemical Structure

CAS No. 95975-55-6

Guggulsterone E&Z Related Products

Biological Activity

Description Guggulsterone is one of the active constituent of Commiphora mukul. It occurs in two isomeric forms, namely Z-GS and E-GS. Guggulsterone act as antagonist ligands for the bile acid receptor, farnesoid X receptor, and as active ingredients responsible for the hypolipidemic activity.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01492998 Terminated
Chronic Hepatitis C
Hospices Civils de Lyon
 January 2010 Not Applicable

Chemical Information & Solubility

Molecular Weight 312.45 Formula

C21H28O2
CAS No. 95975-55-6 SDF --
Smiles CC=C1C(=O)CC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 21 mg/mL ( (67.21 mM) Warmed with 50°C water bath; Ultrasonicated; Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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