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ME-344

Name: ME-344
Brand: Selleck Chemicals
SKU: S9736
Rating: 5 (1 reviews)

Catalog No.S9736 Purity:≥99%

ME-344 directly targets the OXPHOS complex 1, a pathway involved in the production of ATP, in the mitochondria. Treatment of tumor cells with ME-344 as a single agent results in a rapid loss of ATP and cancer cell death.ME-344 results in inhibition of cell growth and viability in all the leukemia cell lines with IC50 values in the range of 70–260 nM.

ME-344 Chemical Structure

CAS No. 1374524-68-1

Purity & Quality Control

≥99

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Biological Activity

Description

Targets

OXPHOS complex 1 ^[1]
(in all the leukemia cell lines test)

70–260 nM

References

[1] Roth KG, et al. Trends Mol Med. 2020;26(1):119-134.

Chemical Information & Solubility

Molecular Weight	348.39	Formula	C₂₂H₂₀O₄
CAS No.	1374524-68-1	SDF	--
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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