Home Neuronal Signaling AChR agonist LY2119620 For research use only.

LY2119620

LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.

LY2119620 Chemical Structure

LY2119620 Chemical Structure

CAS No. 886047-22-9

Purity & Quality Control

Batch: S736601 DMSO]87 mg/mL]false]Ethanol]10 mg/mL]false]Water]Insoluble]false Purity: 99.81%
99.81

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Signaling Pathway

AChR Signaling Pathways

AChR Signaling Pathway

Biological Activity

Description LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.
Targets
M2 muscarinic acetylcholine receptor [1] M4 muscarinic acetylcholine receptor [1]
In vitro
In vitro LY2119620 displays modest allosteric agonism and positively modulates the functional G protein–signaling ability of an agonist at the M2/M4 receptor subtypes by placing the M2 and M4 receptors into an active G protein–bound state. LY2119620 enhances the potency of three muscarinic acetylcholine receptor agonists, ACh, Oxo-M and iperoxo. [1] [3H]LY2119620 can be used as a probe for the human M(2) and M(4) muscarinic receptor allosteric binding sites. [2]

Chemical Information & Solubility

Molecular Weight 437.94 Formula

C19H24ClN5O3S
CAS No. 886047-22-9 SDF Download LY2119620 SDF
Smiles CC1=C2C(=C(SC2=NC(=C1Cl)OCC(=O)N3CCN(CC3)C)C(=O)NC4CC4)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 87 mg/mL ( (198.65 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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