Home Metabolism PDE inhibitor Lodenafil For research use only.

Lodenafil

Synonyms: Hydroxyhomosildenafil

Lodenafil (Hydroxyhomosildenafil) is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED).

Lodenafil Chemical Structure

Lodenafil Chemical Structure

CAS No. 139755-85-4

Purity & Quality Control

Batch: E061701 DMSO]100 mg/mL]false]Ethanol]13 mg/mL]false]Water]Insoluble]false Purity: 99.93%
99.93

Lodenafil Related Products

Signaling Pathway

PDE Signaling Pathways

PDE Signaling Pathway

Biological Activity

Description Lodenafil (Hydroxyhomosildenafil) is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED).
Targets
PDE5 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01180283 Completed
Erectile Dysfunction
Cristália Produtos Químicos Farmacêuticos Ltda.
 January 2009 Phase 4
NCT00817830 Withdrawn
Erectile Dysfunction|Coronaropathy
Cristália Produtos Químicos Farmacêuticos Ltda.
 November 2008 Phase 4

Chemical Information & Solubility

Molecular Weight 504.6 Formula

C23H32N6O5S
CAS No. 139755-85-4 SDF --
Smiles CCCC1=N[N](C)C2=C1NC(=NC2=O)C3=C(OCC)C=CC(=C3)[S;v6](=O)(=O)N4CCN(CCO)CC4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (198.17 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 13 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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