Home Metabolism PDE activator Linderane For research use only.

Linderane

Linderane, isolated from Lindera strychnifolia vill., is an indirect PDE3 activator and possesses multiple biological effects, including superoxide anion radical-scavenging and antioxidative activity and protective activity against gastritis, gastric ulcers and backache.

Linderane Chemical Structure

Linderane Chemical Structure

CAS No. 13476-25-0

Purity & Quality Control

Linderane Related Products

Signaling Pathway

PDE Signaling Pathways

PDE Signaling Pathway

Biological Activity

Description Linderane, isolated from Lindera strychnifolia vill., is an indirect PDE3 activator and possesses multiple biological effects, including superoxide anion radical-scavenging and antioxidative activity and protective activity against gastritis, gastric ulcers and backache.
Targets
PDE3 [1]
In vitro
In vitro Linderane inhibits gluconeogenesis by activating hepatic PDE3 in rat primary hepatocytes. It reduces phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, and decreases intracellular cAMP concentration and CREB phosphorylation in rat primary hepatocytes under both basal and forskolin-stimulated conditions. Linderane also increases total PDE and PDE3 activity but not PDE4 activity in rat primary hepatocytes. Linderane indirectly activated PDE3 through extracellular regulated protein kinase 1/2 (ERK1/2) and signal transducer and activator of transcription 3 (STAT3) activation[1].
Cell Research Cell lines rat primary hepatocytes
Concentrations 2.5, 5, 10, 20 μM
Incubation Time 1.5 h
Method

Rat primary hepatocytes are incubated in serum-free, glucose-free Dulbecco's modified Eagle's medium (DMEM) supplemented with metformin (500 μM) or different doses of linderane for 1.5 h, followed by 4 h of incubation in the presence or absence of gluconeogenic substrates (2 mM sodium pyruvate, plus 20 mM sodium lactate) with or without the stimulation of forskolin (20 μM). Medium is collected to determine glucose production.
In Vivo
In vivo Linderane improved glucose and lipid metabolism after chronic oral administration in ob/ob mice[1].
Animal Research Animal Models C57BL/6J mice (male, 8–9 weeks)
Dosages 50 mg/kg
Administration oral

Chemical Information & Solubility

Molecular Weight 260.29 Formula

C15H16O4
CAS No. 13476-25-0 SDF --
Smiles CC1=CCCC23C(O2)C(C4=C(C1)OC=C4C)OC3=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
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DMSO : 52 mg/mL ( (199.77 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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