Home Immunology & Inflammation TNF-alpha inhibitor Lenalidomide hemihydrate For research use only.

Lenalidomide hemihydrate

Synonyms: CC-5013 hemihydrate

Lenalidomide hemihydrate (CC-5013 hemihydrate) is a potent inhibitor of TNF-alpha with a IC50 of 13 nM. It induces tyrosine phosphorylation of CD28 on T cells, which subsequently activates NF-κB. It acts as a ligand for the ubiquitin E3 ligase cereblon (CRBN), leading to the selective ubiquitination and degradation of the lymphoid transcription factors IKZF1 and IKZF3 through the CRBN-CRL4 ubiquitin ligase complex.

Lenalidomide hemihydrate Chemical Structure

Lenalidomide hemihydrate Chemical Structure

CAS No. 847871-99-2

Purity & Quality Control

Batch: E602901 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.18%
99.18

Lenalidomide hemihydrate Related Products

Signaling Pathway

TNF-alpha Signaling Pathways

TNF-alpha Signaling Pathway

Biological Activity

Description Lenalidomide hemihydrate (CC-5013 hemihydrate) is a potent inhibitor of TNF-alpha with a IC50 of 13 nM. It induces tyrosine phosphorylation of CD28 on T cells, which subsequently activates NF-κB. It acts as a ligand for the ubiquitin E3 ligase cereblon (CRBN), leading to the selective ubiquitination and degradation of the lymphoid transcription factors IKZF1 and IKZF3 through the CRBN-CRL4 ubiquitin ligase complex.

Chemical Information & Solubility

Molecular Weight 536.54 Formula

C13H13N3O3.1/2H2O
CAS No. 847871-99-2 SDF Download Lenalidomide hemihydrate SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (186.37 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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