Home Microbiology HCV Protease inhibitor - COVID-19 inhibitor Ledipasvir (GS5885) For research use only.

Ledipasvir (GS5885)

Ledipasvir (GS5885) is a HCV NS5A polymerase inhibitor, used for the treatment of hepatitis C virus infection.

Ledipasvir (GS5885) Chemical Structure

Ledipasvir (GS5885) Chemical Structure

CAS No. 1256388-51-8

Purity & Quality Control

Ledipasvir (GS5885) Related Products

Signaling Pathway

HCV Protease Signaling Pathways

HCV Protease Signaling Pathway

Biological Activity

Description Ledipasvir (GS5885) is a HCV NS5A polymerase inhibitor, used for the treatment of hepatitis C virus infection.
Targets
HCV [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03903185 Completed
Hepatitis C Chronic|Hematologic Malignancy
Ain Shams University|Cairo University
 March 1 2019 Phase 1|Phase 2
NCT03639207 Withdrawn
Hepatitis C Virus
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
 June 15 2018 --
NCT05091008 Completed
Hepatitis C Chronic
Mansoura University Children Hospital
 March 1 2018 Phase 2

Chemical Information & Solubility

Molecular Weight 889.0 Formula

C49H54F2N8O6
CAS No. 1256388-51-8 SDF Download Ledipasvir (GS5885) SDF
Smiles CC(C)C(C(=O)N1CC2(CC2)CC1C3=NC=C(N3)C4=CC5=C(C=C4)C6=C(C5(F)F)C=C(C=C6)C7=CC8=C(C=C7)N=C(N8)C9C1CCC(C1)N9C(=O)C(C(C)C)NC(=O)OC)NC(=O)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (112.48 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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