Home Epigenetics Histone Demethylase inhibitor L-2-Hydroxyglutaric acid disodium For research use only.

L-2-Hydroxyglutaric acid disodium

Synonyms: (S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG

L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.

L-2-Hydroxyglutaric acid disodium Chemical Structure

L-2-Hydroxyglutaric acid disodium Chemical Structure

CAS No. 63512-50-5

Purity & Quality Control

Batch: S132501 Water]38 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.88%
99.88

L-2-Hydroxyglutaric acid disodium Related Products

Signaling Pathway

Histone Demethylase Signaling Pathways

Histone Demethylase Signaling Pathway

Biological Activity

Description

L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.
Targets
Histone Demethylase [1] Mi-CK [2]
(Cell-free assay)		 Mi-CK [2]
(Cell-free assay)
2.52 mM(Km) 11.13 mM(Ki)
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Chemical Information & Solubility

Molecular Weight 192.08 Formula
C5H6Na2O5
CAS No. 63512-50-5 SDF --
Smiles [Na+].[Na+].OC(CCC([O-])=O)C([O-])=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 38 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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