Home PI3K/Akt/mTOR PDK inhibitor JX06 For research use only.

JX06

JX06 is a selective covalent inhibitor of PDK1 in cells. JX06 dose-dependently inhibits PDK1, PDK2 and PDK3 with IC50 0.049 μM, 0.101 μM and 0.313 μM, respectively.

JX06 Chemical Structure

JX06 Chemical Structure

CAS No. 729-46-4

Purity & Quality Control

Batch: S098301 DMSO]65 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.99%
99.99

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Signaling Pathway

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PDK Signaling Pathway

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Kelly Antiproliferative assay 72 hrs Antiproliferative activity against human Kelly cells after 72 hrs by CCK8 assay, IC50=0.289μM. 28230989
A549 Antiproliferative assay 72 hrs Antiproliferative activity against human A549 cells after 72 hrs by CCK8 assay, IC50=0.48μM. 28230989
A549 Antitumor activity assay 40 to 80 mg/kg 21 days Antitumor activity against human A549 cells xenografted in BALB/c nude mouse assessed as reduction in tumor weight at 40 to 80 mg/kg, ip for 21 days measured on day 21 post dose 28230989
Click to View More Cell Line Experimental Data

Biological Activity

Description JX06 is a selective covalent inhibitor of PDK1 in cells. JX06 dose-dependently inhibits PDK1, PDK2 and PDK3 with IC50 0.049 μM, 0.101 μM and 0.313 μM, respectively.
Targets
PDK1 [1]
(Cell-free assay)		 PDK2 [1]
(Cell-free assay)		 PDK3 [1]
(Cell-free assay)
0.049 μM 0.101 μM 0.313 μM

Chemical Information & Solubility

Molecular Weight 324.51 Formula

C10H16N2O2S4
CAS No. 729-46-4 SDF --
Smiles C1COCCN1C(=S)SSC(=S)N2CCOCC2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 65 mg/mL ( (200.3 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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