JX06

Catalog No.S0983 Batch:S098301

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Technical Data

Formula

C10H16N2O2S4
Molecular Weight 324.51 CAS No. 729-46-4
Solubility (25°C)* In vitro DMSO 65 mg/mL (200.3 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5% DMSO 40% PEG 300 5%Tween80 50%saline
2.5mg/ml Taking the 1 mL working solution as an example, add 50 μL of mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of saline to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description JX06 is a selective covalent inhibitor of PDK1 in cells. JX06 dose-dependently inhibits PDK1, PDK2 and PDK3 with IC50 0.049 μM, 0.101 μM and 0.313 μM, respectively.
Targets
PDK1 [1]
(Cell-free assay)		 PDK2 [1]
(Cell-free assay)		 PDK3 [1]
(Cell-free assay)
0.049 μM 0.101 μM 0.313 μM

Protocol (from reference)

Selleck's JX06 has been cited by 1 publication

A novel PDK1 inhibitor, JX06, inhibits glycolysis and induces apoptosis in multiple myeloma cells [ Biochem Biophys Res Commun, 2021, 587:153-159] PubMed: 34875534

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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